This section is on equine internal medicine topics. These are all questions that have been submitted or that I have been inspired to talk about because of a question submitted. If you have any topics that you would like to have discussed please feel free to email me with the topic or question.
Unlike most of the other domestic species, horses do not have the esophageal musculature that would allow them to vomit. This is why obstructions in the intestine are so dangerous because they can lead to rupture of the stomach. Commonly, a nasogastric tube is passed to allow reflux to occur in suspected cases of obstruction.
This condition is called Exercise-Induced Pulmonary Hemorrhage (EIPH) and has been recognized in the horse world since the 16th century. Despite the long recognition of this condition, the underlying cause is still not clear. Many horses (studies show between 50-70%) that are called upon to perform intense exercise such as racehorses experience this but only a few affected horses (2 to 5%) actually show external signs. Since the underlying cause is not known, a successful treatment is not known either.
Colic in horses is a term that refers to abdominal pain resulting from some problem with the digestive tract. Due to the length and shape of horse intestines, intestinal blockages, impactions, torsions, etc are relatively common in horses. Anything from a change in diet to eating gravel can lead to colic. Most colics resolve with nursing care and a little time. Some of them, however, require surgery to correct. Signs of colic include pawing and nipping at the abdomen, restlessness, refusal to eat, and lying down. Gradual changes it diet and restriction from sand and gravel are recommended to help prevent the chances of a horse experiencing colic.
Aspirin and banamine are part of a class of drugs known as non-steroidal antiinflammatory drugs (NSAID). These drugs are used to relieve pain and inflammation as well as to reduce fever. Unfortunately, these drugs also have the potential to cause ulcers in the stomach or intestine. In addition, they can cause laminitis which is a serious disease of the foot that can lead to permanent lameness. If you do have to treat a horse with aspirin or banamine do so at the proper doseage and monitor the horse carefully. Foals seem to be especially susceptible to ulcer formation and it is recommended that anytime foals are treated with NSAIDS, they also be given protective drugs like sucralfate or cimetidine.
Given what you have described I definitely think that an endocrine (or hormonal) problem is a possibility. The symptoms that you have described -- drinking a peeing a lot; a thick, dull coat; chronic laminitis, etc -- is not so indicative of thyroid disease (although it could be) as of a condition called Equine Cushings Disease. His age and the fact he won't gain weight and has good muscling, however, is not consistent with this condition but it is still something to check. Other possibilities with the elevated creatinine include an underlying kidney or bladder problem especially with the frequent urination. You may have already done these things, but ideally I would have your veterinarian pull blood and do a complete blood count, blood cell differential, blood chemistry with fibrinogen, and check hormone levels for thyroid and Chushings disease. That will at least give you information as to how the liver, kidney, etc are functioning and if there is a subclinical infection or site of inflammation in addition to testing the hormone levels. There are several genetic disease unique to Quarter Horses but I cannot think of any that would give the symptoms that you describe.
The two most common causes of weight loss in horses are chronic inflammation and poor nutrition. It sounds as if she is getting plently of good nutrition. Have you had her teeth examined lately? If not, that would be something to consider doing. Chronic inflammation is the second most likely cause of weight loss in horses. She may have a residual unterine infection or inflammation from the abortion. She may have a mesenteric lymph node abscess or any of a number of inflammatory processes. The best way to check for that is to have your vet pull some blood and analyze it for inflammation (complete blood count, white blood cell differential, and fibrinogen). At her age you would have to consider cancer and if you rule-out teeth problems or chronic inflammation you may have to pursue the possibility of cancer.
I have researched and answered these questions to the best of my ability. But I am human and make mistakes. If there is any part of my answer that you feel is incorrect, please let me know. The last thing I want is to disseminate false or incorrect information.