What does the future hold for Calvin and Hobbes?  That's a tricky question.  Either Watterson comes back in some form, or he doesn't.  After five years of being forced to read old comics in the books or on the Internet, people are most likely thinking our beloved duo will never come back.
E-BOOK or another tech allowing Watterson to publish by himself: 35 to 1
        For those of who were subscribed to my New Calvin Times newsletter (that had 3 issues in the one year it was in a semi-existence) might remember how I figured that perhaps with the technology of the e-book, Bill Watterson might return and write comics by himself and wirelessly submit them to his readers directly through a simple subscription.
NEW BOOK: 15 to 1
      On the other hand, others have pointed out the possibility of a treasury coming out with new or even old strips.  While in 1996, 1997, and maybe 1998, this was indeed quite a major possibility; this seems less and less likely.  Of course this may still happen, but as the years go by, (as well at the fifteenth anniversary, a perfect time to release a new book) I do not even think of that as a possibility.
TV SERIES/MOVIE/RETURN TO THE NESPAPERS: Infinity to 1
        Then, comes one of the remotest possibilities, him returning to the comic strips in the newspaper, very unlikely.  Unless Watterson suddenly decides to live with the syndicates and people trying to license his work, he's not going to be coming back to the newspapers.  I really admire Bill Watterson for his integrity and his forceful stands on keeping the comic strip as it is.  I really do think that a C&H motion picture or a TV series would destroy the work.  Thank you, Mr. Watterson for keeping your work as it is.
NOTHING IN THE NEAR FUTURE: Even
        This is the likelist, and I think that that's all I have to say.

      DISCLAMER: The above article is what I think, not what Mr. Watterson thinks.