| Game Title | Protected | Code No | Format | Notes |
| EA Cricket 2000 | NO | PAL EURO | ||
| EA Supercross 2000 | NO | |||
| Eagle One Harrier Attack | YES | PAL EURO | Repeats the replay after the 1st mission with DISK ERROR displayed | |
| Earthworm Jim | NO | PAL & NTSC | ||
| Earthworm Jim 2 | NO | PAL & NTSC | ||
| Echo Night | NO | PAL EURO | ||
| Echo Night | NO | NTSC US | ||
| ECW Anarchy Rules | NO | NTSC US | ||
| ECW Anarchy Rules | NO | SLES-02823 | PAL UK | |
| ECW Hardcore Revolution | NO | NTSC US | ||
| ECW Hardcore Revolution | NO | SLES-02535 | PAL UK | |
| Egypt 1156 B.C. | NO | PAL UK | ||
| Egypte 1156 av.J-C | NO | SLES-01597 | PAL FR | |
| Einhander | NO | NTSC US | ||
| Elamental Gearbolt | NO | NTSC US | ||
| Eliminator | NO | PAL & NTSC | ||
| Epidemic | NO | PAL & NTSC | ||
| Ergheiz | NO | PAL UK | ||
| ESPN Extreme Games | NO | PAL & NTSC | ||
| ESPN Extreme Games 2 | NO | SCES-00063 | PAL EURO | |
| Eternal Eyes | NO | SLES-02270 | PAL EURO | |
| Eternal Eyes | NO | PAL AUS | ||
| Euro 2000 (UEFA) | YES | SLES-02704 | PAL EURO | After the 2nd game on euro 2000 tournament it goes back to the intro |
| Europe Racer | NO | SLES-03415 | PAL AUS | |
| European Super League | NO | PAL UK | ||
| Everybody's Golf | NO | PAL & NTSC | ||
| Everybody's Golf 2 | NO | SCES-02146 | PAL UK | |
| Evil Dead | NO | NTSC US | ||
| Evil Dead Hail To The King | NO | PAL UK | ||
| Evil Zone | NO | PAL & NTSC | ||
| Excalibur 2555 AD | NO | PAL & NTSC | ||
| Exceed My Corpse | YES | NTSC US | ||
| Exhumed | NO | PAL & NTSC | ||
| Explosive Racing | NO | PAL & NTSC | ||
| Extreme 500 | NO | PAL & NTSC | ||
| Extreme Pinball | NO | PAL & NTSC | ||
| Extreme Snowbreak | NO | PAL & NTSC | ||
| Extreme Sports | NO | PAL EURO |