Friday, September 20, 2002
ATLANTA (AP) - Government health officials are warning doctors that
the West Nile virus can cause acute paralysis after the mosquito-borne
virus apparently caused six people to become paralyzed.
The Centers for Disease Control and Prevention urged doctors to test
patients for West Nile if they report sudden, painless paralysis but do
not appear to have had a stroke.
The warning came as health officials confirmed that the West Nile
virus can apparently be transmitted through blood transfusions and said
that all blood donations will probably be screened for the virus as soon
as a test can be developed.
The most serious effect of infection - life-threatening brain
inflammation - occurs in only a small percentage of cases, mostly among
the sick or elderly. But most of the reported paralyses, in Mississippi
and Louisiana, have occurred among middle-aged people who were
previously healthy, CDC medical epidemiologist Jim Sejvar said.
Some of these victims lost the use of an arm or leg; others needed
ventilators to help them breathe.
A CDC report said the symptoms can be confused with a condition known
as Guillain-Barre syndrome. There is no known way to prevent West Nile
paralysis, but Sejvar said treatments for Guillain-Barre syndrome may be
harmful to patients who actually have West Nile.
Health officials also suggested Thursday that the virus can survive
in donated blood for days.
A woman in Mississippi caught West Nile after receiving transfusions
from three infected donors. CDC doctors called that case ``highly
suspicious'' and said that West Nile ``probably can be spread by
transfusion.''
Previously, doctors were not sure whether it was possible to spread
West Nile through blood, although a Georgia case in which donated organs
spread the virus to four recipients in August raised that possibility.
Dr. Jesse Goodman of the Food and Drug Administration said that all
blood donations will probably be screened for the virus as soon as a
test can be developed. He could not predict how long it would take to
develop such a test or how much it would cost.
``What we're trying to do here is jump-start this process,'' he said.
But screening for the virus could prove difficult. West Nile is much
harder to detect than a virus such as HIV because there are relatively
small amounts of West Nile in tainted blood.
Furthermore, a screening would have to detect the virus itself - not
just antibodies the body produces in response - because the virus spends
several days in the blood stream before symptoms show up.
Blood banks said they expected the FDA's announcement. Dr. Louis
Katz, president-elect of industry group America's Blood Centers, said
the important question is not whether West Nile can be transmitted
through blood, because it probably can, but whether it's a threat big
enough to warrant testing all donations for it.
``Does it rise to the level of appropriate screening? That's what we
have to figure out,'' Katz said, adding that some diseases known to be
spread through transfusion aren't screened because they're so rare.
West Nile was first detected in the United States just three years
ago. The CDC has reported more than 1,700 human cases of West Nile virus
so far this year, including 84 deaths.
Most people who become infected with the virus suffer no ill effects
at all; others develop only flu-like symptoms.
Researchers also point out that not all patients who receive tainted
blood will become infected with West Nile. The CDC reported a July case
in which a 55-year-old woman received contaminated blood after an
orthopedic procedure but never tested positive for the virus.
While repeating that the benefits of blood transfusions far outweigh
the risks of catching West Nile, Goodman said patients seeking elective
surgery may want to talk with their doctors about delaying the procedure
or donating their own blood to be used later on themselves.
Source: CDC