The star of the show, Cass is the crazy glue that holds all the other characters and situations together, whether she likes it or not. She lives with her mother and works a number of unskilled jobs, plenty of fodder for her cynical outlook on life.
The yin to Cassidy's yang, her sarcastic male counterpart. Spence is the beneficiary of a sizeable trust fund, so he spends most of his time being "creative", when he's not harassing his friends as they toil at "real" jobs.
A single mom of 6-year-old Penny, Angi has been Cassidy's best friend since kindergarten. She often serves as Cass' ever-so-blunt reality check, and vice versa. She is a horrible driver, and is often dealing with the long arm of the law on the side of some road.
The wild card. If men are from Mars, Marisol hails from somewhere around Seti Alpha 6. A co-worker at Plebeian's, she is the friend Cassidy turns to when she needs a little TLC, though she could end up being schooled in the ponderings of a worm...
Think your mom gets on your nerves? Cassidy has you beat -- we hope. A constant source of frustration for Cassidy, She's an aging hippie who realized too late that peace & love don't amount to squat.
Ms. Peevish and twins Christy and Kristy are Cassidy's supervisors at the bank. Annoying contest? It's a tie!
Angi's six-year-old genius-level daughter. She fluently trades barbs with Angi's friends and co-workers, often getting the better of them, though she occasionally surprises everyone with her childlike innocence and observations.