The greatest scientific breakthrough in Pokemon-dom has finally been achieved -- Mewtwo. Mewtwo was cloned from the DNA of the fossilized remains of Mew, the rarest Pokemon. But when Mewtwo awoke, he found himself encased in glass in a laboratory, prompting him to go on a rampage. As desperate scientists try to keep Mewtwo in check, Mewtwo obliterates the lab and goes off to find the purpose of his existence. The strongest Pokemon has been created, but it's an experiment gone awry. Soon Mewtwo sets its goals higher than humans ever did... now how will Pikachu and co. survive this challenge? This feature also goes back-to-back with a mini-movie, "Pikachu's Vacation".