The wedding and reception will be held at
The Port Royal Clubhouse
Port Royal Plantation
10-A Grass Lawn Ave
Hilton Head, SC 29928
(843) 681-1748

You have two main choices:
Savannah/Hilton Head International Airport.
This airport is approximately 45 minutes from the island.
It is served by several airlines connecting from a few major cities.
There is shuttle service (Low Country Adventures)
available from the airport to the island.
Hilton Head Airport
This airport is right on the island,
very close to the wedding site.
However, it is only serviced by one airline
(US Airways Express) through Charlotte, NC.

Here's some help getting to the Clubhouse:
From New England: Take I-95S all the way
to South Carolina exit 8 - US-278E
toward Bluffton/Hilton Head Island.
278E takes you out to the island.
From Indianapolis: a map
From Savannah: another map
From Little Rock: yet another map