MIDAZOLAM

Calculate the dose of Midazolam to be given by I/V 
infusion for 24 hours.
Weight 40 kg.
Dose 20microgram/hour. 
1 ampoule contains 1 ml solution having 1 mg of Midazolam. 
How much Normal Saline need to be added to run at a 
rate of 1 ml per hour for 24 hour? 

Dose of Midazolam = 20 microgram/kg/hr 
Weight of baby= 40 kg 
Amount of Midazolam required = 20X40 =800 microgram/hr 
So, in 24 hours total amount of Midazolam required= 800X24 =19200 microgram 

In the ampoule, 1 ml= 1 mg or, 1000 microgram Midazolam 
Now, 1000 microgram Midazolam is present in 1 ml 
So, 1 microgram Midazolam is present in 1/1000 ml 
So, 19200 microgram Midazolam is present in 1X19200/1000 ml= 19.2 ml 

Now, Midazolam solution is to be run at a rate of 1 ml per hour for 24 hour. 
So, total amount required to be given in 24 hours = 1X24= 24 ml 

Hence, amount of Normal saline to be added= 24-19.2 ml= 4.8 ml