Joseph F. Margiotta, Ph.D.
(State University of New York at Stonybrook, 1981)
Associate Professor, Neurobiology
Department of Anatomy and Neurobiology
Medical College of Ohio
[email protected]
Block Health Science Building
3035 Arlington Ave.
Toledo, OH 43614
Dr. Margiotta's research is focused on the mechanisms that control synaptic transmission in cholinergic neurons. The techniques of molecular biology and single-channel and whole-cell recording are used to investigate regulatory mechanisms that control the expression of diverse ion channel properties of nicotinic receptors in different populations of cholinergic neurons. Other studies explore the molecular basis for expression of proteins that cause receptor aggregation in cholinergic synapses in neurons and muscle cells.
Recent Publications
- Burns, A. L., D. Benson, M. J. Howard, and J. F. Margiotta. 1997. Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses (rapsyn). Journal of Neuroscience. 17(13):5016-26.
- Thornhill W. B., M. B. Wu, X. Jiang, X. Wu, P. T. Morgan, and J. F. Margiotta. 1996. Expression of Kv1.1 delayed rectifier potassium channels in Lec mutant Chinese hamster ovary cell lines reveals a role for sialidation in channel function. Journal of Biological Chemistry. 271(32):19093-8.
- Howard, M. J., M. D. Gershon, and J. F. Margiotta. 1995. Expression of nicotinic acetylcholine receptors and subunit mRNA transcripts in cultures of neural crest cells. Developmental Biology. 170(2):479-95.
- Margiotta, J. F., and D. Pardi. 1995. Pituitary adenylate cyclase-activating polypeptide type I receptors mediate cyclic AMP-dependent enhancement of neuronal acetylcholine sensitivity. Molecular Pharmacology. 48(1):63-71.
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