U.S. Federal Route 52 is a east-west highway through Hamilton County. Much of this runs on the expressway system of Greater-Cincinnati. U.S. Rt. 52 passes through the following towns in Hamilton County. Harrison Cincinnati U.S. Rt. 52 is multi-plexed in Hamilton County. Interstate 74, from the Ohio/Indiana State Line to Cincinnati. Interstate 275, near Miamitown.