Ohio State Route 49 is a north-south highway in Williams County. This is the western most north-south highway in the county. It connects Edgerton, and Edon to the Ohio Turnpike. OH St Rt 49 passes through the following towns in Williams County. Edgerton Edon OH St Rt 49 is multi-plexed in Williams County. U.S. Rt. 20, near Columbia.
OH St Rt 49 intersects the following highways in Williams County. U.S. Rt. 6, at Edgerton. Ohio State Route 34, at Edon. Ohio State Route 107, near Edon. Interstate 80, near Columbia. Interstate 90, near Columbia. Ohio Turnpike, near Columbia. U.S. Rt. 20, near Columbia.