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Alternate

To unlock a different costume simply beat the game with Dante.

Alternate Costume (Lucia)   

For Lucia's other outfit simply beat the game with Lucia.

Be Sparda   

While in battle when your life gets in the red. Devil Trigger and instead of becoming your normal demon form.Dante will transform into Sparda

Lucia's 2nd alternate costume  

To unlock this you need to beat the game on "Lucia's Hard Mode".

Unlock "Dante/Lucia must die mode"   

To do this you will need to need to beat either characters "Hard Mode".

Unlock Arius Secretary  

Beat Lucia Must Die mode with lucia. You will unlock Arius' Secretary which looks similar to Lucia and uses those same weapons.

Unlock the Bloody Palace 

To do this you must beat the game with both Dante and Lucia.

Unlock Trish from the first game (DMC1) 

To achieve this you must beat the game in "Dante's Hard Mode".