The 1999 San Francisco 49ers Schedule
| DATE | OPPONENT | TIME |
| SEP. 12 | At Jacksonville | 1:15 PM |
| SEP. 19 | NEW ORLEANS | 1:05 PM |
| SEP. 27 | At Arizona | 6:00 PM (Mon) |
| OCT. 3 | TENNESSEE | 1:15 PM |
| OCT. 10 | At St. Louis | 10:00 AM |
| OCT. 17 | CAROLINA | 1:15 PM |
| OCT. 24 | At Minnesota | 10:00 AM |
| OCT. 31 | BYE | BYE |
| NOV. 7 | PITTSBURGH | 1:15 PM |
| NOV. 14 | At New Orleans | 10:00 AM |
| NOV. 21 | ST. LOUIS | 1:15 PM |
| NOV. 29 | GREEN BAY | 6:00 PM (Mon) |
| DEC. 5 | At Cincinnati | 10:00 AM |
| DEC. 12 | ATLANTA | 1:15 PM |
| DEC. 18 | At Carolina | 1:15 PM (Sat) |
| DEC. 26 | WASHINGTON | 5:20 PM |
| JAN. 3 | At Atlanta | 6:00 PM (Mon) |
All Times Are Pacific Daylight/Standard
