Anime Turnpike - This site has almost anything related to anime you could possibly imagine. From multimedia to fansubs to info on your favorite series.
Best Anime - A database of anime series, complete with images, movie clips and reviews. If you're looking for a new series and want some helpful info, go here, damn it!
Hitoshi Doi's Page - There's not much I can say about this guy that hasn't been said already. Basically this page has any info you could ask for on Seiyuu, and I've never seen a more extensive episode guide to Sailor Moon.
A Fallen Angel: Shrine to Angel Sanctuary - Lovely page dedicated to Angel Sanctuary, and to one of the best manga artists out there. Also a Lucifer shrine for all you Kira lovers...(I think I'll have to make a Katan shrine one of these days, no one appreciates the guy)
Whitecross Homestead - A thorough page of another favorite anime of mine. There's an awesome translation of the OVA script on this site.
Yami no Matsuei - Descendants of darkness, this site has an amazing section of translations andinfo on characters, anime (13 episodes) and manga.
Houshin no Miko's Houshin Engi Site - I have yet to find a person more thorough on this manga based off an old Chinese novel. It has great manga scans and what has to be the most extensive character info page (and there are ALOT of characters).
Path of Blood - A site dedicated to Peace Maker, a manga by Kurono Nanae about the Shinsengumi. Lovely layout and a large amount of helpful content. I'm just discovering this manga, but already I love it, since I LOVE Okita Souji!!
Animenation - Alittle on the expensive side, relatively speaking, and sometimes it takes forever for them to get things once they're back logged. But its worth a shot.
Nikaku Anime Art - One of the cheapest book resource and a good start to finding import videos and cds. Fairly large selection. I've ordered from them and they were extremely reliable!
Acclimate Solutions - Ultimate site for savings. Shipping is a bit of a drag only because it's imported direct from Japan, and not everyone will pay for airmail. But they have great titles and I've never had a problem. Also they provide translations for what you buy. Pretty Handy!
Japan CD - Looking for a hard to get CD, DVD, VCD, or Video. Try this site. Caution though, for animation, prices can be steep (like $70 for VHS)
Fansub Database - Need or want a fansub title? You have to go here first! The only problem is there are a lot of "future projects" not "completed projects" But I know how expensive and time consuming subtitling is, and it's worth being patient!
Omocha Box - This is one of the GREATEST resources for manga artists in the US. They have many hard to find things like comic tones, G and maru pens (sorry, no kabura, I had to go to Japan to get mine). They also sell otaku merchandise, anime and CD's. I've never had a problem with them except when something is "on order", then it takes a while to get it. And their prices are the cheapest. eg. a ten pack of maru pens costs $10.50, elsewhere you'll pay inthe range of $15-$20. I sound like an infomercial. Buy now, while supplies last!
Miscellaneous
Eigomanga - A site dedicated to showcasing original, amateur comics and manga. Very COOL flash design. They seem to always be upgrading their technology, so there's periodic updates. We've started to submit our work here.
Zelda Comic - Hahaha!!! One funny ass site! I love the original Legend of Zeldas and this brings back old memories *tear*. You do have to have played the originals to really get some of the humor (young 80's child) though.
Pocket Bishounen - Funniest site ever. Wanna see the 99 I've caught: click here