| Year | Event | Source |
| 320 | Vulcans and Romulans achieve warp capability | Star Trek: Star Charts |
| 370 | Confederacy of Surak, the official name of Vulcan, founded due to Great Awakening on Vulcan | Star Trek: Star Charts |
| 930 | Klingons achieve warp capability | Star Trek: Star Charts |
| 1154 | Andorians achieve warp capability | Star Trek: Star Charts |
| 1571 | First interstellar solar-sail flight from Bajor to Cardassia | Explorers |
| 1925 (?) | Cardassians achieve warp capability | Star Trek: Star Charts |
| 1947 | Quark's shuttle crash lands in Roswell, Arizona | Little Green Men |
| 1966 | Viral experiment wipes out all adult life on Miri | Miri |
| 1968 | Gary Seven begins work for Aegis on Earth | Assignment: Earth |
| 1969 | Apollo XI lands on Earth's Moon | |
| 1970 | Khan Noonien Singh born | Eugenics Wars |
| 1986 | U.S.S. Enterprise-A retrieves a pair of humpback whales to answer probe attacking Earth in 2286 | The Voyage Home |
| 1992-96 | Eugenics Wars | Eugenics Wars |
| 1996 | DY-100 sleeper ship S.S. Botany Bay, developed at Area 51, stolen by Gary Seven and presented to Khan to end Eugenics Wars | Eugenics Wars |
| 2020 | Shaun Christopher lands on Titan; landing site named Christopher's Landing | Tommorow is Yesterday |
| 2024 | Bell Riots in San Francisco | Past Tense |
| 2032 | Zefram Cochrane born | Metamorphosis |
| 2039 | Lunar Colonies founded (Earth's moon) | Star Trek: Star Charts |
| 2050s | World War III | First Contact |
| 2063 | Cochrane launches Phoenix and makes first contact with Vulcans (April 5) | First Contact |
| 2078 | Optimum Movement reaches height of power, sparking the rekindling of World War III | Bread and Circuses
Encounter at Farpoint |
| 2079 | Postatomic Horror | Miri
Encounter at Farpoint |
| 2087 | S.S. Conestoga lands on Terra Nova | Star Trek: Star Charts |
| 2093 | Coridan achieves warp capability | Star Trek: Star Charts |
| 2103 | Mars terraformed and colonized as United Martian Colonies | The 37s
Star Trek: Star Charts |
| 2113 | United Earth government founded | Star Trek: Star Charts |
| 2151 | U.S.S. Enterprise NX-01, the first warp-5 starship, launched (April 11) | Broken Bow |
| First contact with Andorians (July 15) | The Andorian Incident |
| Contact re-established with Terra Nova colony | Star Trek: Star Charts
Terra Nova |
| 2153 | First contact with Tellarites | Bounty |
| 2156-60 | First Romulan War | Balance of Terror |
| 2160 | Romulan Neutral Zone established | Balance of Terror |
| 2161 | Establishment of the United Federation of Planets (Earth, Vulcan, Andoria, Tellar and Alpha Centauri were founding members) | Star Trek: Star Charts |
| 2165 | Sarek of Vulcan born | Sarek |
| 2178 | Terra Nova admitted to United Federation of Planets | Star Trek: Star Charts |
| 2183 | S.S. Horizon lands on Epsilon Bootis III and establishes Izar Colony (location of StarFleet Tactical School) | Star Trek: Star Charts |
| 2202 | United Rigel Colonies (Beta Rigel II, IV, V, VI & X) admitted to United Federation of Planets | Star Trek: Star Charts |
| 2222 | Montgomery Scott (Scotty) born | |
| 2223 | Deltans achieve warp capability and admitted into UFP | Star Trek: Star Charts |
| 2227 | Leonard McCoy born | Encounter at Farpoint |
| 2230 | Spock born | |
| 2233 | James T. Kirk born | |
| 2236 | S.S. Columbia crash lands on Talos IV with sole survivor | The Cage
The Menagerie |
| 2237 | Spock and T'Pring bonded | Amok Time |
| Hikaru Sulu born | |
| 2239 | Uhura born | |
| 2242 | Scotty starts starship career | |
| 2243 | McCoy meets Emony Dax at Ole Miss | Trials and Tribble-ations |
| 2245 | Pavel Chekov born | |
| 2246 | Kodos the Executioner kills 4000 on Tarsus IV; Kirk survives along with Kevin Riley | Conscience of the King |
| 2249 | Risa admitted to United Federation of Planets | Star Trek: Star Charts |
| 2250 | Kirk assigned to U.S.S. Republic as first-year cadet | Court Martial |
| 2251-62 | U.S.S. Enterprise under command of Christopher Pike | |
| 2252 | Spock assigned to U.S.S. Enterprise | The Cage |
| 2253 | Spock graduates Academy and posted to U.S.S. Enterprise | |
| 2254 | Kirk graduates Academy and posted to U.S.S. Farragut as Lieutenant | Obsession |
| Kirk leads survey mission on Neural | A Private Little War |
| Half of the crew of the U.S.S. Farragut killed by cloud vampire | Obsession |
| First contact with Rigel VII by U.S.S. Enterprise | Star Trek: Star Charts |
| 2257 | Kirk attends Command School where he meets Janice Lester | Turnabout Intruder |
| 2259 | U.S.S. Hornet commissioned |
| Deneb V achieves warp capability and admitted into United Federation of Planets | Star Trek: Star Charts |
| Ardana achieves warp capability | Star Trek: Star Charts |
| 2260 | Chad Young born (January 4) |
| 2261 | S.S. Beagle makes contact with Magna Roma | Bread and Circuses |
| 2263 | Chekov graduates Academy and assigned to U.S.S. Enterprise | |
| Ardana admitted into United Federation of Planets | Star Trek: Star Charts |
| 2264 | Kirk promoted to Captain and placed in command of U.S.S. Enterprise | |
| Scotty named Chief Engineer of U.S.S. Enterprise | |
| U.S.S. Enterprise encounters Balok of the First Federation | Corbomite Maneuver |
| Romulans discovered to be an offshoot of Vulcans | Balance of Terror |
| Kirk attempts to steal a Romulan cloaking device | The Enterprise Incident |
| Kelly Jean O'Connor born (June 12) | |
| 2265 | Spock named First Officer of U.S.S. Enterprise and promoted to Commander | |
| Sulu assigned as staff physicist on U.S.S. Enterprise | |
| U.S.S. Enterprise discovers S.S. Botany Bay adrift; Khan and his followers are exiled to Ceti Alpha V after a failed takeover of the Enterprise | Space Seed
The Wrath of Khan |
| Cassandra MacLoad born | |
| Cestus III colony founded | Star Trek: Star Charts |
| 2266 | McCoy named Chief Medical Officer of U.S.S. Enterprise | |
| Uhura named communications officer on U.S.S. Enterprise | |
| Sulu transferred to helm, U.S.S. Enterprise | |
| Jayme and Jessica Kirk born | |
| 2267 | T'Pring divorces Spock | Amok Time |
| First contact with Gorn in conflict over Cestus III | Arena |
| Organian Peace Treaty | Errand of Mercy |
| Capella and Miri become protectorates of the United Federation of Planets | Star Trek: Star Charts |
| Coridan admitted to United Federation of Planets | Star Trek: Star Charts |
| 2268 | U.S.S. Enterprise sent to Sycorax to determine whether a colony of genetically-engineered supermen should be admitted into the Federation | Eugenics Wars |
| Neural becomes a protectorate of the United Federation of Planets | Star Trek: Star Charts |
| 2269 | McCoy contracts xenopolycythemia, a fatal disease, which is cured by the information gained from the computer which runs Yonada | For the World is Hollow and I Have Touched the Sky |
| First contact with Tholians | The Tholian Web |
| Ardanian society reunified by Kirk | The Cloudminders |
| Kirk promoted to Admiral and placed in charge of fleet operations at Earth | |
| Spock retires from StarFleet to complete kohlinar | The Motion Picture |
| Scotty promoted to Commander, oversaw refit of U.S.S. Enterprise | The Motion Picture |
| Chekov promoted to Lieutenant and named Security Chief of U.S.S. Enterprise | The Motion Picture |
| Ridika Myers born (December 18) | |
| 2270 | McCoy retires to enter private practice | The Motion Picture |
| Sulu promoted to Lieutenant Commander and assigned to U.S.S. Enterprise | The Motion Picture |
| 2271 | Uhura promoted to Lieutenant Commander | The Motion Picture |
| V'Ger comes to Earth | The Motion Picture |
| Spock reactivated during V'Ger mission | The Motion Picture |
| Jade Drak'nah born (March 28) | |
| Diplomatic relations established between United Federation of Planets and Tholians | Star Trek: Star Charts |
| Cestus III resettled by Humans and Gorn according to Metron treaty | Star Trek: Star Charts |
| 2272 | Benjamin Jamison born (August 9) |
| 2273 | Betazed admitted into United Federation of Planets | Star Trek: Star Charts |
| 2274 | Rusty Hemd born |
| 2275 | Son'a expelled from Ba'ku | Insurrection |
| 2277 | Kirk appointed to Academy faculty | |
| Spock promoted to Captain; assigned to Academy faculty and cadet training | The Wrath of Khan |
| Chekov assigned to U.S.S. Reliant | The Wrath of Khan |
| Uhura assigned to Academy cadet training and StarFleet Command communications | The Wrath of Khan |
| Sulu assigned to Academy cadet training and StarFleet Command helm operations | The Wrath of Khan |
| 2281 | Young graduates Academy and assigned to U.S.S. Excalibur | |
| 2282 | Young promoted to Lieutenant Junior Grade | |
| 2283 | O'Connor starts Academy | |
| 2285 | Young promoted to Lieutenant and transferred to U.S.S. Trinity | |
| Scotty promoted to Captain with oversight of transwarp drive for U.S.S. Excelsior | The Search for Spock |
| Chekov promoted to Commander and First Officer of U.S.S. Reliant | The Wrath of Khan |
| Khan captures Genesis device | The Wrath of Khan |
| Spock dies | The Wrath of Khan |
| Spock is reborn | The Search for Spock |
| David Marcus dies | The Search for Spock |
| Kirk demoted to Captain for failure to obey direct orders | The Voyage Home |
| Trill admitted into United Federation of Planets | Star Trek: Star Charts |
| 2286 | O'Connor graduates Academy and assigned to StarFleet Security on Earth | |
| Whale-searching probe attacks Earth | The Voyage Home |
| U.S.S. America NCC-1776 commissioned | |
| 2287 | O'Connor assigned to U.S.S. Alexis | |
| Uhura assigned to U.S.S. Enterprise-A as communications officer | The Final Frontier |
| Sybok hijacks U.S.S. Enterprise-A | The Final Frontier |
| U.S.S. America destroyed | |
| U.S.S. Hornet renamed U.S.S. America NCC-1776-A | |
| 2288 | O'Connor promoted to Lieutenant Junior Grade | |
| Young promoted to First Lieutenant and assigned to Deep Space Station K-4 | |
| 2289 | O'Connor transferred to U.S.S. America-A | |
| Curzon Dax meets Kor, Kang and Koloth | Blood Oath |
| Tuvok enters StarFleet Academy | Flashback |
| 2290 | O'Connor promoted to Lieutenant | |
| Young promoted to Lieutenant Commander | |
| Sulu promoted to Captain and given command of U.S.S. Excelsior | The Undiscovered Country |
| 2291 | O'Connor promoted to First Lieutenant | |
| 2292 | Alliance between Klingon and Romulan Star Empire collapses | Reunion |
| 2293 | O'Connor promoted to Lieutenant Commander and transferred to U.S.S. Concordia; promoted to Commander after helping to rescue Enterprise-B from Nexus ribbon | |
| Young transferred to U.S.S. Challenger | |
| U.S.S. Excelsior detects explostion of Praxis | The Undiscovered Country |
| Khitomer Accord | The Undiscovered Country |
| Kirk presumed dead during U.S.S. Enterprise-B maiden voyage | Generations |
| Tuvok graduates Academy and assigned to U.S.S. Excelsior | Flashback |
| 2294 | U.S.S. Challenger destroyed; crew reassigned to U.S.S. Monitor | |
| Jamison graduates Academy; assigned to U.S.S. America-A | |
| Scotty presumed missing from U.S.S. Jenolen after retirement | Relics |
| Spock takes command of U.S.S. Intrepid II with Uhura as First Officer and McCoy as Chief Medical Officer. |
| 2295 | O'Connor promoted to Captain and given command of the U.S.S. America-A | |
| Young and Jessica Kirk transferred to U.S.S. America-A | |
| Myers and Drak'nah graduate Academy and posted to U.S.S. America-A | |
| Jayme Kirk promoted to Captain and assigned to U.S.S. Defiant |
| Young promoted to Commander; DeLaney to Lieutenant; MacLeod and Drak'nah to Lieutenant Junior Grade |
| 2296 | The Andorian Ambassador announces the secession of the Andorian delegation from the United Federation of Planets |
