Interstate 6 parallels much of the Rio Grande in Texas.  It branches off from I-10 in Van Horn, and goes through the cities of Laredo, McAllen and Brownsville.  This exit list goes from west to east, so if you're going westbound, you need to start at the bottom and go up.
I-10 (El Paso/Phoenix)(San Antonio/Houston)
TX 54/Van Horn

C-1523/Van Horn Mountains Trail
Lobo
Chispa Mountain Road
C-2017/Van Horn Mountains Trail
Valentine
C-505/Fort Davis
US 67 South/TX 17 (Marfa)
TX 118/Alpine
US 67 North/Fort Stockton
Marathon
US 385 (Fort Stockton/Big Bend National Park)
US 285/Fort Stockton
Sanderson
TX 349/Dryden
C-1865/Pumpville
Langtry
C-1024/Pandale
TX 163 (Comstock/Juno)
I-27/US 277/US 377 (Del Rio/San Angelo)
US 90 (Del Rio/Uvalde)
C-693/Brackettville
Quemado
C-1908/Spofford
Normandy
TX 131/Spofford
US 57/US 277 (Eagle Pass/Carrizo Springs)
El Indio
C-1472 (Laredo)
I-35 (Laredo/San Antonio)
C-1472/Mines Road
Del Mar Blvd/Old Santa Maria Road
Spring Road
Hillside Road
Calton Road
I-69 (Laredo/Houston)/US 59 (Saunders Road)
Lyon Street
Clark Blvd
Corpus Christi Street
Guadalupe Street/Chihuahua Street
Meadow Avenue
US 83/Sacred Heart Drive
El Cenzio
San Ygnacio
Ramireno
TX 16/Zapata
Siesta Shores
C-2687/Guerra
Lopeno
Falcon
Falcon Heights
Salineno
Roma
Escobares
C-3167/El Sauz
C-755 (Rio Grande City/La Gloria)
Santa Cruz
Garciasville
Sullivan City/Los Ebanos
La Joya
Mission
US 83 (Laredo/McAllen)
TX 107 (McAllen/Edinburg)
C-396/Mission Road
C-494/Taylor Road
Ware Road
29th Street
C-115/23rd Street
Main Street
TX 336/10th Street
McColl Road
C-2061/C-3420 (Pharr/Edinburg)
US 281 (Pharr/Edinburg)
C-1426 (Pharr/San Juan)
C-2557
Weslaco/Elsa
Mercedes
US 77 North/Raymondville
La Paloma/San Benito
US 77 Business/Harlingen
(CONTINUED)
TX 100/Laguna Vista
Viejo
Olmito
US 77 South/US 83 South (Brownsville)
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