Finally it was confirmed that Rena (or should I say Hidemi) and Eisuke were actually Sister and Brother.

What surprised me in this file was that Ethan was the one who killed himself, in a way that looks as if his daughter killed him. He bit his own hand, and shot himself from under his chin so that the organization does not notice the blood on his mouth from the bite.

Ethan did all that just to protect his daughter...