| Week 1 | |||||||||||
| Brian | Charlie | Dan | Dennis | E&S | Jason | Jon | Wilski | ||||
| 1 | C | Piazza, Mike | McCann, Brian | Johjima, Kenji | Martinez, Victor | Iannetta, Chris | Mauer, Joe | Hernandez, Ramon | Posada, Jorge | ||
| 2 | 1B | Teixeira, Mark | Fielder, Prince | Lee, Derrek | Pujols, Albert | Kotchman, Casey | Howard, Ryan | Gonzalez, Adrian | Morneau, Justin | ||
| 3 | 2B | Lugo, Julio | Cano, Robinson | Barfield, Josh | Roberts, Brian | Kendrick, Howie | Utley, Chase | Burke, Chris | Weeks, Rickie | ||
| 4 | 3B | Cabrera, Miguel | Glaus, Troy | Zimmerman, Ryan | Rolen, Scott | Wright, David | Ramirez, Aramis | Lowell, Mike | Chavez, Eric | ||
| 5 | SS | Tejada, Miguel | Jeter, Derek | Young, Michael | Guillen, Carlos | Ramirez, Hanley | Drew, Stephen | Reyes, Jose | Rollins, Jimmy | ||
| 6 | OF | Abreu, Bobby | Jones, Andruw | Francoeur, Jeff | Crawford, Carl | Beltran, Carlos | Ramirez, Manny | Sizemore, Grady | Soriano, Alfonso | ||
| 7 | OF | Guerrero, Vladimir | Burrell, Pat | Damon, Johnny | Dye, Jermaine | Drew, J.D. | Suzuki, Ichiro | Lee, Carlos | Rios, Alexis | ||
| 8 | OF | Matsui, Hideki | Hunter, Torii | Cuddyer, Michael | Holliday, Matt | Markakis, Nick | Berkman, Lance | Baldelli, Rocco | Ordonez, Magglio | ||
| 9 | Res 1 | Rodriguez, Alex | Konerko, Paul | Swisher, Nick | Beltre, Adrian | Atkins, Garrett | Hafner, Travis | Gordon, Alex | Thome, Jim | ||
| 10 | Res 2 | Teahen, Mark | Wells, Vernon | Lopez, Felipe | Huff, Aubrey | Milledge, Lastings | Dunn, Adam | Hall, Bill | Giambi, Jason | ||
| 11 | Res 3 | Helton, Todd | Sweeney, Mike | Ibanez, Raul | Kinsler, Ian | Marte, Andy | Bonds, Barry | Kouzmanoff, Kevin | Jones, Chipper | ||
| 12 | Res 4 | Mora, Melvin | Thomas, Frank | Kearns, Austin | Ortiz, David | Young, Delmon | Delgado, Carlos | Freel, Ryan | Garciaparra, Nomar | ||
| 13 | Res 5 | Youkillis, Kevin | Taveras, Wily | Willingham, Josh | Patterson, Corey | Peralta, Jhonny | Young, Chris B. (OF) | Bay, Jason | Blalock, Hank | ||
| 14 | Res 6 | Ethier, Andre | Upton, BJ | Phillips, Brandon | Sheffield, Gary | Kubel, Jason | Pierre, Juan | Sexson, Richie | Overbay, Lyle | ||
| 15 | Res 7 | Crisp, Coco | Kent, Jeff | Baker, Jeff | Tracy, Chad | Crosby, Bobby | Roberts, Dave | LaRoche, Adam | Uggla, Dan | ||
| 16 | |||||||||||
| 17 | SP 1 | Santana, Johan | Bonderman, Jeremy | Smoltz, John | Bedard, Erik | Cain, Matt | Zambrano, Carlos | Halladay, Roy | Oswalt, Roy | ||
| 18 | SP 2 | Schilling, Curt | Kazmir, Scott | Verlander, Justin | Carpenter, Chris | Billingsley, Chad | Harden, Rich | Hamels, Cole | Peavy, Jake | ||
| 19 | SP 3 | Schmidt, Jason | Hudson, Tim | Young, Chris R. (P) | Gorzellany, Tom | Myers, Brett | Sheets, Ben | Haren, Dan | Webb, Brandon | ||
| 20 | SP 4 | Zito, Barry | Capuano, Chris | James, Chuck | Perez, Oliver | Olsen, Scott | Hernandez, Felix | Willis, Dontrelle | Burnett, A.J. | ||
| 21 | SP 5 | Arroyo, Bronson | Sabathia, C.C. | Lackey, John | Sanchez, Anibal | Patterson, John | Beckett, Josh | Francis, Jeff | Harang, Aaron | ||
| 22 | RP 1 | Hoffman, Trevor | Wickman, Bob | Ryan, B.J. | Fuentes, Brian | Ray, Chris | Torres, Salomon | Jones, Todd | Rodriguez, Francisco | ||
| 23 | RP 2 | Isringhausen, J. | Benitez, Armando | Street, Huston | Nathan, Joe | Wainwright, Adam | Borowski, Joe | Weathers, David | Papelbon, Jon | ||
| 24 | RP 3 | Wagner, Billy | Broxton, Jonathan | Jenks, Bobby | Putz, J.J. | Soriano, Rafael | Otsuka, Akinori | Dempster, Ryan | Saito, Takashi | ||
| 25 | WC 1 | Cordero, Chad | Maine, John | Reyes, Al | Rivera, Mariano | Morrow, Brandon | Julio, Jorge | Buehrle, M. | Gordon, Tom | ||
| 26 | WC 2 | Cordero, Francisco | Santana, Ervin | Reyes, Anthony | Valverde, Jose | Matsuzaka, Daisuke | Hill, Rich | Pettitte, Andy | McDougal, Mike | ||
| 27 | |||||||||||
| 28 | Inactive | Butler, Billy | Cantu, Jorge | Podsednik, Scott | Cameron, Mike[1] | Braun, Ryan | Cabrera, Daniel[2] | Alou, Moises | Wood, Brandon[3] | ||
| 29 | Inactive | Gonzalez, Mike | Jacobs, Mike | Duffy, Chris | Clemens, Roger | Miller, Andrew | Coffey, Todd | Bailey, Homer | Maybin, Cameron | ||
| 30 | Inactive | Mussina, Mike | McCarthy, Brandon | Garko, Ryan | Encarnacion, Edwin | Hughes, Phillip | Crede, Joe | Bruce, Jay | Jackson, Connor | ||
| 31 | Inactive | Prior, Mark | Owens, Henry | Hensley, Clay | Escobar, Kelvim | Duchsherer, Justin | Riske,David | Duncan, Chris | Igawa, Kei | ||
| 32 | Inactive | Upton, Justin | Penny, Brad | Lidge, Brad | Pelfrey, Mike | Greinke, Zack | Granderson, Curtis | Jones, Adam | Monroe, Craig | ||
| 33 | Inactive* | Tulowitzki, Troy | Thornton, Matt | Shealy, Ryan | Hamilton, Josh | Hart, Corey | Victorino, Shane | Pence, Hunter | |||
| 34 | Inactive* | Varitek, Jason | Wheeler, Dan | Zumaya, Joel | Garza, Matt | Howry, Bob | Snell, Ian | ||||
| Lincecum, Tim | |||||||||||
| D.L. | D.L. | D.L. | Dotel, Octavio | ||||||||
| McPherson, Dallas[4] | Mulder, Mark[5] | Johnson, Josh[6] | D.L. | D.L. | |||||||
| Wang, Chien-Meng | Gagne, Eric | Johnson, Randy[7] | Figgins, Chone[8] | D.L. | Garcia, Freddy | D.L. | |||||
| Lee, Cliff | Rivera, Juan[9] | Martinez, Pedro[10] | Liriano, Francisco[11] | Sanchez, Freddy | Clement, Matt | ||||||
| Wood, Kerry[12] | Weaver, Jered | Furcal, Rafael | |||||||||
| Quentin, Carlos | |||||||||||
| Hermida, Jeremy | |||||||||||