Kidney: Infarct

1.    What pathological process does it illustrate?

Ischemic coagulative necrosis

2.    Describe the configuration of lesion and explain why it is so?

They are wedge shaped, with the base against the cortical surface and the apex pointing towards the medulla.  There may be a narrow rim of preserved subcortical tissue that has been spared by the collateral capsular circulation.

3.    Name the structures affected by the process.

Nephrons

4.    Name 2 possible causes.

Global hypoperfusion due to cardiac failure.

Renal artery stenosis leading to reduced blood flowing to kidneys.

5.    Is the process reversible?

 No.

6.    What is the final outcome of this lesion?

Fibrous scarring giving rise to depressed, pale, grey-white scar that assume V shape on section

7.    What is the status of the other kidney?

Normal

8.    True / False MCQs. Clinical features in this condition includes:

1. Fever � true if there is infections

2. Back pain � true

3. Haematuria � true

4. Leucopenia - false

5. Dysuria - false

6. Casts in urine - true

7. Protein in urine - true

8. Decrease in urine output - true

9. Leg oedema - true

10. Always symptomatic � false

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Copyright � Joseph Ong 2003