Coronary artery: Fresh thrombus
1.
What are the anatomical features to indicate that this is a coronary artery?
Features of an artery
It is next to myocardium
2.
What
is the most probable risk factor in this patient for the pathological process to
occur at this site? Is it evident
in the slide?
Atherosclerosis is the pathological process.
Risk
factor � high cholesterol and lipid levels
Evident in the slides as cholesterol cleft spaces and lipid
3.
Compare
and contrast the early and late stages of luminal lesions with respect to
Key
histopathologic features
Age
of lesion
Consequence
as a result of the lesion and effects on the myocardial perfusion
Fates
fo the lesion
General
principles of ways of treating patients with such lesions (early vs. late)
|
|
Fresh
thrombus |
Organised
Thrombus |
|
a. |
Fibrin
threads Trapped
RBC |
Dense
collagen threads Cholesterol
cleft spaces Capillary
recanalisation |
|
b. |
Few
hours |
Weeks
to months |
|
c. |
Myocardial
infarct leading to coagulative necrosis |
Adaptation
by collateral circulation |
|
d. |
Patient
is likely to die |
Patient
survives for a longer period of time |
|
e. |
Administer
anti-thrombin and tissue plasminogen activator |
Undergo
coronary bypass or angioplasty and advise on a healthy lifestyle in the
future |
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Copyright � Joseph Ong 2003