Normal histology	Histopathology	Pathological basis of disease	Clinical findings	
Sinusoid lining cells:
•	Sinusoids have flattened condensed nuclei & poorly stained cytoplasm.
•	Hepatocytes are exposed on each side to the sinusoids which are lined by a discontinuous layer of sinusoid lining cells.
•	These are supported by the fine reticulin framework of the liver with the space of Disse between the lining cells & the hepatocyte surface.
•	Via the gaps in the sinusoid lining, the space of Disse is continuous with the sinusoid lumen, thus bathing the hepatocyte surface with plasma.
•	Numerous irregular microvilli extend from the hepatocyte surface into the space of Disse, greatly increasing the surface area for metabolic exchange.	Abnormal histology:
•	Well demarcated lesion.
•	Lesion is characterized by the presence of multiple large vascular channels.
•	Vascular channels are lined by endothelial cells.
•	Lumen of these channels are filled with red blood cells.
•	Vascular channels are separated by bands / trabeculae / septa of fibrous & connective tissue embedded with fibroblasts. 	•	Haemangiomas are benign tumors of blood vessels common childhood.
•	Cavernous haemangiomas are particularly common in the liver. 
•	They are distinguished by the formation of large, cavernous, vascular channels, typically forming unencapsulated but discrete lesions, usually 1-2cm in diameter.
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