Pharmacokinetics, Pharmacodynamics, Pharmacology of Autonomic nervous system drugs, Autocoids
71. Noradrenaline is the neurotransmitter at:
a. F
b. F
c. F
d. T
72. Which of the following compounds is / are related to the structure of catecholamines?
a. T
b. F
c. F
d. T
73. Which of the following statements concerning infusion of catecholamines is / are true?
a. F: noradrenaline increases systolic and diastolic pressure but causes no change in stroke volume and therefore no increase in pulse rate.
b. T
c. F: isoprenaline has negligible vasoconstrictor effects.
d. T: noradrenaline causes vasoconstriction at beta1 receptors.
74. The following refer to sympathomimetic drugs:
a. F: some act by inhibiting the uptake of catecholamines into nerve endings or by inhibiting its metabolism.
b. F
c. T
d. T: amphetamine is an alkaline drug and its excretion is impaired at high pH.
75. Which statement(s) is / are true concerning adrenoceptor antagonists?
a. T
b. F
c. T
d. T
76. Neuromuscular blockade is antagonized by:
a. T: inhibits acetylcholinesterase thereby increasing free ACh at the NMJ.
b. F: potentiate neuromuscular blockade mainly by interference with ion channel function.
c. F
d. F: potentiate neuromuscular blockade by decreasing ACh release.
77. In the isolated rabbit small intestine preparation,
a. F
b. T
c. F
d. T
78. Plasma T1/2 of a drug:
a. F
b. T
c. F
d. F
79. Acetylcholine is the neurotransmitter at:
a. T
b. F
c. T
d. T
80. D-tubocurarine:
a. T
b. F: produces non-depolarizing type of neuromuscular blockade.
c. F: D-tubocurarine has a duration of action of 50min compared to succinylcholine (5 - 10 min).
d. T