CURRICULUM VITAE

PERSONAL INFORMATION

Name:                              Lyman Wuchao Yuan
Citizenship:                      China, and Permanent resident, USA
Current Address:            45 Brownlow Road, London NW10 9QS, UK
Phone:                             +44(0)7906 478491
Email:                              [email protected]

EDUCATION

Temple University School of Medicine, Philadelphia, PA, USA (1992-1996)
Ph.D., Molecular Biology and Genetics, May 1996
GPA: 3.5

Ohio University, Athens,OH, USA (1989-1991)
Ph.D. program in Molecular and Cellular Biology / Botany / Chemistry
GPA: 3.7

Clemson University, Clemson,SC, USA (1987-1989)
Master of Science, Plant Pathology and Physiology, August 1989
GPA: 3.12

Beijing Agricultural University, Beijing, China (1978-1982)
Bachelor of Science, Plant Pathology, April 1982
GPA: 3.5

RESEARCH AND TEACHING EXPERIENCE

Postdoctoral Research Assistant
Department of Crystallography, Birkbeck College University of London
2002 to 2003
Conduct two research projects:

Structural basis for histone acetyltransferase (HAT) and transcriptional functions of human tumor suppressor protein p300, and

Structural study of Agrobacterium VirE2 protein required for transformation of plant cells.

Postdoctoral Research Associate
Department of Physiology and Biophysics, Boston University School of Medicine
2001 to 2002
Conducting researches on expression, purification and structural studies of human low desity lipoprotein receptor.

Postdoctoral Fellow
Oregon Cancer Center, Oregon Health Sciences University
1997 to 2000
Designed and conducted relatively independent researches on regulation of the tumor suppressor protein p300 function including:

Establishment of a chromatin-based in vitro assay system to determine the transcriptional coactivator function

Identification of a major phosphorylation site (serine 89) in p300 in vivo and of its responsible kinase PKCd

Determination of inhibitory effect of the phosphorylation on the histone acetyltransferase and transcription functions

Analysis of the p300 phosphorylation on cell cycle events at G1 and differentiation

Postdoctoral Fellow
Lab of Biochemistry and Molecular Biology, The Rockefeller University
1996
Conducted researches on two projects:

Functional analysis of the initiator-binding basal transcription factor TFII I

Chromatographic fractionation of p300/CBP complexes in HeLa nuclear extracts

Ph.D. Student
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
1992 to 1995
Conducted researches in three areas:

• Functional analysis of the human p300 protein as a transcriptional coactivator for the myogenic regulator MyoD;
• Molecular mechanisms involved in tissue-specific expression of the c-myb proto-oncogene at the level of transcription elongation;
• Expression of a recombinant retinoic acid receptor binding protein (RARBP1)

Research Associate
Molecular and Cellular Biology Program / Botany Department / Chemistry Department, Ohio University
1989-1991
Conducted the following researches:

• Promoter analysis of the PHO81 gene in Saccharomyces cerevisiae
• Isolation and characterization of cDNA clones encoding the potato tuber lectin

Teaching Associate
Botany Department, Ohio University
1989-1990
Participated in teaching of "Principles of Biology" course

Research Assistant
Department of Plant Pathology & Physiology, Clemson University
1987 to 1989
Conducted researches including:

• Identification of Prunus Necrotic Ringspot Virus isolates isolated frompeach trees
• Immuno-analysis on distribution of the virus in peach trees
• Investigation of transmission of the virus by nematodes

Assistant
Department of Plant Pathology, Beijing Agricultural University
1982 to 1987
Duties including:

• Undergraduate advisor
• Participated in teaching of "Phytobacteriology" and "Phytopathology" courses
• Conducted researches including isolation, characterization and functional analysis of plant bacterial pathogens and their phages

HONOR

• NIH National Research Services Award for Postdoctoral Training, Oregon Cancer Center, 1997-2000
• Award for Grant-in-Aid of Research from Sigma Xi, the Scientific Research Society, 1995
• Award for Graduate Training Fellowship, Fels Institute, Temple University School of Medicine, 1992-1995
• Achievement recognition in "Who's Who among International Students in American Universities and Colleges", 1991
• Award for the John Houk Memorial Research Grant, Ohio University, 1990.
• Award for Excellence in Teaching, Beijing Agricultural University, 1984.
• Award for Academic Excellence, Beijing Agricultural University, 1981.