Dear IBSVoice Panelist, Many of our panelists have asked us to update them on DrugVoice's IBS survey results and the impact we are having in the IBS community. So far, over 2,000 people have completed the extensive IBSVoice survey, which makes it one of the largest and most far-reaching studies of IBS patients ever conducted. As expected, people have their own unique ways of managing their IBS, but there are common themes such as: 1. Frustration With Physicians Although a minority of IBS panelists think their physicians are wonderful, most of you are frustrated and dissatisfied with how physicians treat IBS patients. Many physicians need to better understand IBS and the difficulties it can create in their patients' lives, to improve how they interact with their IBS patients. 2. Lack of Safe, Reliable and Effective IBS Therapies Most panelists want new options - drugs or alternative therapies - that have a greater impact on their symptoms, especially the ability to prevent symptoms. Lotronex was an effective solution for a number of panelists with diarrhea-predominant IBS, but many others reported the type of side effect issues that ultimately led to the removal of this product from the market. 3. Trial and Error Disease Management Many panelists rely on significant trial and error to treat their particular mix of symptoms. They try various combinations of diet, stress management, medications, and alternative therapies to arrive at a solution that works for them. It's clear from the wide variety of responses that there is not a "one size fits all" solution for our panelists. Many of you have joined the DrugVoice IBS panel specifically to make a difference in IBS treatment. Aggregate data from the survey (without any personally identifying information) have been shared with and used by 3 major pharmaceutical companies, 2 nutritional product manufacturers, and leading IBS physicians to help them better understand IBS from the patient's perspective. DrugVoice has also shared our findings with the Lotronex Action Group (http://www.lotronexactiongroup.org), who are lobbying the FDA to return Lotronex to the market, as well as with the IBS Self Help Group (http://www.ibsgroup.org), a leading community of IBS sufferers. We are working to broaden access to others in the medical community who would benefit from learning more about IBS patients. During the next few months, DrugVoice will conduct additional surveys with panel members on particular IBS issues. If your background matches our survey criteria, and you agreed to participate in additional surveys, you will receive an e-mail invitation from DrugVoice asking for your input. We hope that you will take advantage of this opportunity to keep making an impact on IBS treatment. Thank you for your continued input and commitment to helping the IBS patient. Yours Truly, Melissa Krauth President, DrugVoice LLC http://www.drugvoice.com