Public Affairs
GlaxoSmithKline
Research Triangle Park, N.C.  27709

April 3, 2001

RE: Lotronex


Dear Ramona Duboise:

It is the understanding of the Lotronex Action Group from both the Food and Drug
Administration and GlaxoSmithKline that talks are being held currently regarding
the re-introduction of Lotronex to the market.  While talks have been on-going
for several months, we would like to remind those with GSK that Lotronex has
been off the market for over five months.  I need not remind those at GSK that
this has been five months of needless suffering for those whom have
substantially benefitted from Lotronex.  I would, however, like to remind you
that no affective alternative treatment exists for the symptoms of IBS with
diarrhea which include severe abdominal discomfort, multiple urgent daily bouts
of diarrhea, depression, panic attacks, social introversion and a variety of
other symptoms.

The Lotronex Action Group steering committee and full membership are extremely
disappointed and frustrated with the pace of action on both sides.  As we
realize this is a complicated issue, we urge you to work with the FDA to make
this issue a top priority and resolve it as soon as possible.

While the LAG believes both sides are working in good faith to resolve the
issue, we question why the negotiations are taking so long.  For those of us
whom benefitted greatly from Lotronex, the issue is simple.  We had access to
the only medicine that allowed us to live normal lives without pain and
suffering from our illness and now we do not.

We trust you will forward this email to the appropriate parties within GSK.

Also, we would like to reaffirm to all involved parties that the Lotronex Action
Group is a grass-roots group of people whom formerly used and benefitted from
Lotronex.  The LAG is not affiliated nor receives any funding from any
pharmaceutical company.

Sincerely,

The Lotronex Action Group
<lotronexactiongroup@yahoo.com>

Tom Bell, Coordinator
Richard Fireman, Coordinator
Corey Miller, Coordinator

In partnership with IBS Self Help Group
Jeffrey Roberts, President & Founder