Biological Abnormalities of the Borderline Personality Disorder Dr. Heller discusses these biological abnormalities in the BPD in his book Life at the Border 1) Abnormal neurological exams ("soft signs") 2) Abnormal REM sleep 3) Brain wave (EEG) abnormalities 4) Impaired access to memory 5) Cases caused by brain trauma & infection 6) Abnormal circadian (daily biological) rhythms 7) Abnormal sound and language processing 8) Abnormal cellular biology 9) Impaired visual perception 10) Impaired visual perception 11) Symptoms similar to epilepsy in temporal lobes Home