Rheumatic arthritis
Nevertheless, the data from a few quality studies discussed above are suggestive that glucosamine is effective in the control of pain symptoms and is potentially a disease-modifying agent in the treatment of knee OA. rheumatic arthritis Rehabilitation and osteoarthritis and knee. When taken orally, it is safe but there are few long-term data. Glucosamine may thus be effective in decreasing the symptoms of OA; however it should be recommended to patients with the attitude that additional long-term efficacy studies need to be performed. (top of section)(top of page) Chondroitin SulfateFrequently sold in combination with glucosamine, chondroitin sulfate is a proteoglycan and a major component of articular cartilage. rheumatic arthritis Angina pains. It is hypothesized to work by increasing levels of chondroitin sulfate in the blood and subsequent incorporation into the cartilage. Additionally, in vitro studies have demonstrated that chondroitin sulfate can stimulate production of other important cartilage proteoglycans. ref 4 & 7 A number of clinical studies have now demonstrated that chondroitin sulfate therapy does indeed produce clinical benefits. rheumatic arthritis Causes-of-lower-abdominal-pain. Bourgeois et alref 8 conducted a multicenter, randomized, double-blind, controlled study which compared 1200 mg/day chondroitin sulfate to placebo. One hundred twenty-seven patients were randomized to receive either placebo, chondroitin sulfate 1200 mg/day, or chondroitin sulfate 3x400 mg/day. In the chondroitin sulfate groups, the Lequesne's Index, and the patient and physician overall assessments were significantly improved compared to baseline (P<0. 01 for both assessments). In contrast, there was only a slight improvement observed in the placebo group. Both the physician's and patient's overall efficacy assessments were significantly better in the chondroitin sulfate group than in the placebo group (P<0. 01). Of note, there was no difference in efficacy between the single dose of 1200mg chondroitin sulfate and the 3x400mg daily doses of chondroitin sulfate for any of the clinical parameters studied. Morreale, et alref 9 conducted a randomized, multicenter, double blind, double dummy study comparing the efficacy of chondroitin sulfate with diclofenac sodium, a commonly used anti-inflammatory drug. One hundred forty-six patients with OA of the knee were randomized to receive either chondroitin sulfate or diclofenac sodium for six months.
Rheumatic arthritis
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