Lost Souls in Doom and Doom II are portrayed as floating skulls with horns on the front of their forehead and flames coming out the back of their heads. They have 100 HP and their attack consists in charging forward in an attempt to ram their intended target. A direct hit from a weapon on a charging Lost Soul will force the creature from the direction of the hit, halting its attack. Upon death, Lost Souls will explode in a cloud of flame and smoke, leaving behind no corpse. Owing to their attack type these demons are particularly susceptible to cause monster infighting between their own similars or against other creatures, especially when they appear in large groups. In Doom II, Lost Souls can also be spawned by Pain Elementals.

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