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QSAR of antineoplastics V:
Exploration of receptor interaction sites of antitumor
N-(7-indolyl)benzenesulfonamides targeting GI phase using
electrotopological state atom index.
Roy K, Pal DK,
Sengupta C.
Division of Pharmaceutical Chemistry, Seemanta
Institute of Pharmaceutical Sciences, Mayurbhanj, Orissa, India.
[email protected]
Quantitative structure activity
relationship (QSAR) study of antiproliferative activities of
N-(7-indolyl)benzenesulfonamides with electrotopological state atom
(ETSA) index corroborates the conclusions of the previously reported
Hansch analysis that the structural requirements for interactions with
receptors of human KB nasopharynx cell line are different from that for
murine colon 38 and P388 leukemia cell lines. The study suggests that
both phenyl ring and indole moiety are the important receptor
interaction sites present on the ligands for the murine cell lines,
while the latter site does not appear to play significant role in case
of human KB cell carcinoma.
PMID: 11469751 [PubMed - indexed for
MEDLINE]
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