RESEARCH EXPERIENCE IN INDUSTRY

   SEP 2003- AUG 2007: WORKING WITH PROCITIUS RESEARCH CENTRE (SANMAR SPECIALITY CHEMICALS)

PERUNGUDI, CHENNAI. (www.sanmargroup.com)

 

Was working on process for the first year, where in had the experience of transferring technology from the lab to the plant. The role involved interfacing between lab, plant and the customer.

 

Later moved to drug discovery project as a project coordinator. Reporting directly to the customer was one of the main job. The job done was greatly appreciated by both the customer as well as the company. Almost all the projects were met with the specified time lines.  

 

2006-07 was working on drug discovery projects.

 

Additional responsibilities include

 

a)The safety aspects: Look into the adherence of safety norms by one and all in the Lab.

 

b)Lecture: Giving lectures on topics of interest as a part of training for freshers.

 

FELLOWSHIPS/ AWARDS

 

·        NCERT fellowship for B.Sc.Ed from 1989-1993.

·        NCERT fellowship for M.Sc.Ed from 1993-1995.

·        CSIR/NET examination December 1994 and in June 1995.

·        Dr. Welch’s Foundation Fellow 2002-03.

 

EXPERIENCE AND SKILLS

 

·        Synthesis of Natural Products.

·        Chemical analysis: IR, NMR, Mass, GC, HPLC, LCMS.

·        Operation of 60MHz Geol NMR and also 200MHz and 300 MHz Bruker NMR.

·        Operation of IR instrument Perkin Elmer 683B.

·        Working with Hyperchem.

·        Decently versed with the use of SAP.

 

 

LIST OF PUBLICATIONS

 

a)        Zinc and iodine as a novel catalyst for transesterification and synthesis of substituted 4-methyl coumarins: Subhash P. Chavan, Shivasankar. K, Ramesh R. Kale  Tetrahedron Letters 2002, 43, 8583-86.

b)        Reformatsky reaction of a-chloroesters with carbonyl compounds with commercially available zinc: Subhash P. Chavan, Shivasankar. K, Sivappa. R Journal of Chemical research 2004, 406.

c)        Simplistic, expedient and practical Synthesis of Lipoic acid: Subhash P. Chavan, Shivasankar. K, Pasupathy. K. Synthesis 2005, 1297.

d)        Short and Efficient Synthesis of (±)-A-factor: Subash P.Chavan, K. Pasupathy and Shivasankar. K  Synthetic communication, 2004, 397-404.

e)        A Simple and Efficient Method for Transesterification of ß-Ketoesters Catalysed by Iodine: Chavan, Subhash P.; Kale, Ramesh R.; Shivasankar, K.; Chandake, Sanjay I.; Benjamin, Swapnanjali B.: Synthesis 2003, 2695.

f)          Zirconia-cerria mixed oxide an effective catalyst for transferhydrogenation: Subhash P. Chavan, Shivasankar. K, Sahu, H. R. (to be Communicated)

g)        Dehydration mechanism of thionyl chloride and pyridine: An insight Naraharisastry. G, Shivasankar. K, Devapriyakumar. U, Subhash P. Chavan. (Manuscript under preparation)

 

 

HIGHLIGHTS OF MY Ph. D THESIS

 

            a-Lipoic acid widely distributed in plants and animals as a vital cofactor in enzyme complexes. It has been shown to have significant physiological and pharmacological properties. Cost effective, short synthesis has been attempted starting from easily available cyclohexanone. The use of synthetic methodology developed is put into use for the synthesis.

            Computational study on dehydration mechanism of alcohols, using thionyl chloride and pyridine, with Gaussian and Hyperchem.

Development of new and novel synthetic methodologies to synthesis useful intermediates

a)       Hetero Diels–Alder reaction utilised for the synthesis of 3-Methyl-2-(2-pyridyl)quinoline from the imine of benzaldehyde and pyridine2-carboxaldehyde.

b)       Transesterfication of b-keto esters using zinc and iodine

c)       Zinc and iodine mediated synthesis of substituted 4-Methyl Coumarins from Methyl acetoacetate and phenol.

d)       Reformatsky reaction on less active a-chloroesters with carbonyls