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| Gene therapy for Hepatoma | |||||||||||
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| Trichosanthin inactivates eukaryotic ribosome and blocks cellular protein synthesis by removal of the adenine residue at position 4324 on the 28S rRNA via the N-glycosidase activity. Toward different types of cells, trichosanthin exerted varying degrees of toxicity. Results from clinical studies proved it to be a very effective drug in treating tumors of trophoblastic origin. In this study, we introduced trichosanthin gene into hepatoma cells and placed this suicide gene under the control of a hepatoma specific promotor. It resulted in restricted cellular expression of trichosanthin leading to the selective killing of the tumor cells. |
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