| Osborne Lady Bulldogs (22-4, 8-0) | Roster | ||
| 11/30/2007 | PLAINVILLE CARDINALS* | W | 59-23 |
| 12/4/2007 | vs. Kensington Goldbugs# | W | 81-36 |
| 12/7/2007 | at Lakeside Knights# | L | 50-51 |
| 12/13/2007 | vs. Tipton Cardinals# | W | 56-18 |
| 12/20/2007 | ELLIS RAILROADERS* | W | 51-41 |
| 1/4/2008 | at Norton Bluejays* | W | 54-48 |
| 1/7/2008 | LINCOLN LEOPARDS | W | 57-16 |
| 1/8/2008 | PHILLIPSBURG PANTHERS | W | 52-40 |
| 1/14/2008 | TREGO GOLDEN EAGLES** | W | 39-37 |
| 1/18/2008 | vs. Norton Bluejays** | W | 34-30 |
| 1/19/2008 | vs. Phillipsburg Panthers** | W | 45-35 |
| 1/22/2008 | BELOIT TROJANS | L | 39-42 |
| 1/25/2008 | at Stockton Tigers* | W | 66-43 |
| 2/1/2008 | TREGO GOLDEN EAGLES* | W | 57-24 |
| 2/8/2008 | at Phillipsburg Panthers* | W | 61-46 |
| 2/12/2008 | at Sylvan Unified Mustangs | W | 46-32 |
| 2/14/2008 | LAKESIDE KNIGHTS | W | 61-41 |
| 2/15/2008 | HILL CITY RINGNECKS* | W | 67-30 |
| 2/18/2008 | SMITH CENTER LADY RED | W | 67-33 |
| 2/21/2008 | at Smith Center Lady Red* | W | 49-39 |
| 2/25/2008 | BENNINGTON BULLDOGS^ | W | 63-33 |
| 2/28/2008 | vs. Minneapolis Lions^ | W | 51-36 |
| 3/1/2008 | vs. Washington County Tigers^ | W | 37-17 |
| 3/5/2008 | vs. Pittsburg-Colgan Panthers~ | W | 46-43 |
| 3/7/2008 | vs. St. John Tigers~ | L | 33-46 |
| 3/8/2008 | vs. St. Marys Bears~ | L | 41-52 |
| #-Lakeside Preseason Tournament | |||
| *-Mid-Continent League Game | |||
| **-Mid-Continent League Tournament @ Hays | |||
| (1st Rd. @ Higher Seed) | |||
| ^-2A Sub-State @ Ell-Saline (1st Rd-High Seed) | |||
| ~-2A State @ Manhattan | |||
| Mid-Continent League Tournament Champions | |||
| Mid-Continent League Champions (8-0) | |||
| Ell-Saline 2A Sub-State Champions | |||