In 1994 and 1995, Gless and her television partner, Tyne Daly, joined together to recreate their title roles in a quartet of critically acclaimed and popular "Cagney & Lacey" television movies which they fondly call "The Menopause Years". Other television series in which she starred include "Switch," "House Calls," and the short-lived, but critically lauded Steven Bochco half-hour, "Turnabout." Gless has received much acclaim for dramatic roles in such television movies as "Separated By Murder," "Hard Hat and Legs," "Honor Thy Mother," "Hobson's Choice," "Letting Go," among others, as well as the mini-series, "The Immigrants," "The Last Convertible," "Centennial," and Garson Kanin's "Moviola: The Scarlett O'Hara Wars, in which she played Carole Lombard.

Gless' theatrical film credits include a featured role in the suspenseful and thought-provoking film, "The Star Chamber," which starred Michael Douglas. She has recorded several 'Books on Tape' and starred in numerous radio plays, one of which, "'Night, Mother," for the BBC, garnered her the International Sony Award. She has starred twice on stage in London's famed "West End," the first time in 1993 with Bill Paterson, where she created the role of Annie Wilkes in Stephen King's "Misery" at the Criterion Theater, and four years later, opposite Tom Conti, in Neil Simon's "Chapter 2," at the Gielgud Theater.

She recently starred at Chicago's Tony Award-winning playhouse, The Victory Gardens Theater, in Claudia Allen's "Cahoots," as well as several stints, including an evening at Madison Square Garden with the National Company of Eve Ensler's "The Vagina Monologues." Gless made her stage debut in Lillian Hellman's "Watch on the Rhine" at Stage West in Springfield, Mass.

She's currently staring in her third series of Queer as Folk.