| Strikeouts | |||
| Players | Teams | SO | IP |
| Martinez, P | D-OH | 331 | 293.1 |
| Johnson, R | FALL | 262 | 267.1 |
| Brown, K | RUST | 249 | 290.2 |
| Colon, B | FALL | 197 | 187.0 |
| Leiter, A | KIDS | 182 | 199.1 |
| Glavine, T | VIKE | 179 | 267.0 |
| Person, R | VIKE | 178 | 170.1 |
| Ankiel, R | ASPS | 176 | 180.0 |
| Hudson, T | KIDS | 173 | 193.1 |
| Park, C | GOLD | 168 | 222.2 |