Danger Mouse is about the wacky adventures of a Secret Agent Mouse, and his trusty bumbling hamster sidekick, Penfold. Penfold is lovingly daft, and usually needs to be saved from one situation or another. Together, they are given assignments by Colonel K, their commander/walrus. The orders usually consist of doing battle to save the world from monsters, master thieves, and crazed fiends of all types with the most common being their arch nemesis frog, Baron Silas Greenback and his henchman crow, Stiletto.

The television screen blares and DM knows that it will be Colonel K. wanting them to save the world again. DM is always saving the world - tho as he likes to point out in enumerable British style "it's just a job really." However, DM always manages to save the day, earning himself the adoration of millions who tend to reward him with many unique gifts such as a camel (given to him by eskimos), a 3 toed sloth, a tiger, and even a mongolian wild mule.

There are rarely any humans to be seen apart from the Minister of Inkblots and Inertia, a cleaning man, and an overseas reporter interviewing elephants. All of the other characters are humanized animals.

Danger Mouse and his trusty sidekick Penfold, spend most of their time protecting the world from their arch enemy, the evil Baron Silas Greenback and his henchmen. Clearly a spoof of the many James Bond episodes, it is heavily riddled with witty remarks of all types.

In an episode titled "Custard" they travel to an alien planet where Penfold accidently awakens a cartoon version of Alien, breaking out of it's egg to plant a big wet sucky kiss on Penfold. They then wind up crashing into the moon and getting to earth via a "time travelers potting shed." For Raiders of the Lost Ark fans, there was an episode titled "The Long Lost Crown Affair" where the episode opens within a temple hidden in the South American jungle; where DM and Penfold are chased by a huge ball that turns out to be part of a huge game of snooker.

Danger Mouse lives in a red pillar mailbox just outside the Baker Street home of Sherlock Holmes. Just as James Bond loves his gadgets DM drives the greatest car ever given to any secret agent...not to mention his very nimble "Space Hopper".