| Naloxone | ||||||||||||||
| Thebaine derivative competitive opioid antagonist which competes with opioids at opiate receptors. | ||||||||||||||
| Indications: Respiratory depression induced by narcotic overdose. Asphyxia neonatorum. |
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| Contraindications: Hypersensitivity, respiratory depression. |
Common Side Effects: Induction of severe pain when administered too quickly to those with physiologic narcotic addiction. Potentially Lethal Side Effects: Ventricular tachycardia/fibrillation. |
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| Adult dosing*: Narcotic Overdose: Very slow IV Push <2mg, Alternate routes: IM, SQ, ETT Titrated to return of spontaneous ventilation or level of consciousness |
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| Pediatric dosing*: Asphyxia neonatorum: Very slow IVpush <0.1mg/kg, Max 10mg by all routes Alternate routes: IM, SQ, ETT Titrated to return of spontaneous ventilation or level of consciousness |
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| Notes: - Rapid or non-judicious administration of Naloxone (Narcan) can induce acute withdrawal in patients who may be physiologically narcotic-dependent. |
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