| Dopamine | ||||||||||||||
| Adrenergic catecholamine which causes increased cardiac output. It acts on alpha and beta-1 receptors, causing peripheral vasoconstriction, messenteric/renal vessel dilation (lower range doses), and increased inotropic effects. | ||||||||||||||
| Indications: Shock, non-traumatic hypotension, CHF/Pulmonary Edema, symptomatic bradycardia, post-resuscitation hypotension refractory to fluid therapy, hypotension refractory to fluids in tx of snakebite, |
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| Common Side Effects: Headache, palpitations, tachcardia, hypertension, ectopy, angina, widening of QRS, nausea, vomiting, diarrhea Potentially Lethal Side Effects: Gangrene |
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| Contraindications: Hypersensitivity, ventricular fibrillation, tachydysrhythmias, pheochromocytoma, use within 2 weeks of MAOIs (hypertensive crisis), See drug reactions in Notes below.* |
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| Adult dosing*: 2-20 mcg/kg/min, titrated to SBP >90 |
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| Pediatric dosing*: 2-20 mcg/kg/min, titrated to age-appropriate BP |
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| Notes: * Interactions: MAOIs within 2 weeks (hypertensive crisis) Ergots (severe hypertension) Beta and Alpha blockers (decrease effect of Dopamine) TCAs (Increase of pressor effects) ----------------------------------------------------- -Dopamine is not first line treatment in patients suspected of volume depletion based on clinical presentation. Fluid therapy is more appropriate first line treatment. ----------------------------------------------------- |
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| Infusion preparation: Add 400 mg Dopamine to 250 ml NaCl for solution of 1600mcg/ml |
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