Professor Auxiliar

Instituto de Ciências Biomédicas de Abel Salazar
Largo Abel Salazar, 2
4099-003 Porto

++ 351 22 206 2288

++ 351 22 206 2232

[email protected]

http://www.geocities.com/jose_ac_pereira/

Computational applications to the study of complex equilibria and biomimetical systems. Prebiotic chemistry.
The development of observation and modelization of complex chemical systems have a great number of applications that span from engineering to the origin of life. A less classical approach to modelization of such systems uses cellular automata. These and other systems, categorized under Artificial Chemistry, are being developed.
Nucleotide prebiotic chemistry is an interesting aspect of chemical evolution and is being study using the techniques mentioned above. Several aspects of activated nucleotide association, polymerization, and hydrolysis are very important to understand the appearance of the first oligonucleotides on a complex chemical and physical environment. The spontaneous organization of open CSTR (continuous stirred tank reactor) systems containing activated nucleotides is a major interest for the future.

1H and 31P NMR study of ADP and GDP spontaneous synthesis from 2-methylimidazole-activated AMP and GMP nucleotides and inorganic phosphate
José Pereira, Ana Cadete
J. Chem. Soc., Perkin Trans. 2, 1143-1148 (1999) (corresponding poster in PDF)

Further constituents of Achillea Ageratum
L., Anake Kijjoa, Luís Vieira, José Pereira, Artur M. S. Silva, Werner Herz
Phytochemistry, 51, 555-558 (1999)

An extended cellular automata method applied to the simulation of auto-catalytic and self-replicative molecular behaviour
José Pereira
Second European Conference on Computational Chemistry, Lisboa, 1997 (poster in PDF)

Germacranes and flavonoids from ACHILLEA AGERATUM
Luís M. Vieira, Anake Kijjoa, José Pereira, Thomas Gedris, Werner Herz
Phytochemistry, 45, 111-115 (1997)

Isolation of the mutual transverse dipolar relaxation of a pair of coupled spins
T. J. Norwood, José Pereira
J. Magn. Reson. Series A, 112, 160-168 (1995)

Multinuclear NMR and potenciometric studies on the interaction of Zinc and Cadmium with Cytidine and Glycylglycine. The effect of the anion
Baltazar de Castro, José Pereira
J. Inorg. Biochem., 45, 53-64 (1992)