Renu John

Assistant Professor

Department of Biomedical Engineering

Indian Institute of Technology, Hyderabad

Medak Dist

Andhra Pradesh 502 205

Ph. No. 91-40-23016097

           91-8985156631

Email: [email protected]

Permanent Address

Kizhakkeveettil,

Kanjirappally P O

Kottayam

Kerala

India 686507

Ph: 91-4828 202134

 

   

Research goals

The goal of biomedical imaging is to provide structural and functional information and to visualize biological processes from the nanoscale, to the molecular, cellular, and systems scale. Optical imaging modalities like optical coherence tomography (OCT) and coherence microscopy are emerging as promising modalities for imaging at molecular levels allowing scientists to identify, follow and quantify subcellular biological processes and pathways within a living organism. Molecular imaging is expected to play an important role in oncology, for example, by aiding the early detection of malignancies, locating metastatic disease, staging tumors, evaluating the availability of therapeutic targets, and monitoring the efficacy of treatment. We aim at the development of novel molecular contrast agents and mechanisms that can exploit the high sensitivity of interferometric optical imaging modalities. Novel nanoparticle-based probes can not only provide molecular contrast, but also would serve as agents for therapy and drug delivery applications. The nanoprobes at a cellular level can be exploited to study the biomechanical properties.  

 

Research Interests

  • Novel non-invasive bio-imaging techniques, Coherence imaging and microscopy techniques, Optical coherence tomography (OCT), Optical Fourier domain imaging (OFDI), Molecular contrast agents and Targeted molecular imaging, Nanoparticles, Targeted drug delivery and Biophotonics applications. 
  • Optics and photonics research covering Fourier optics and optical information processing, Optical pattern recognition, Neural networks and correlators, Holographic data storage, and optical data security, Digital holography, Photorefractives, Biological and polymer materials for optics.

                                                                                    

EDUCATION

PhD

Physics

IIT, Delhi, India

GPA: 9/10

Feb 2006

M Sc

Physics

Cochin University, Kerala, India

First class with Distinction (76.9%) 

April 1999

B Sc

Physics

Mahatma Gandhi University, Kerala, India

First class with Distinction (87 %) 

March 1996

RESEARCH EXPERIENCE

Post Doctoral Experience

 

 
Research Associate Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana Champaign, Illinois                            May 2008-Nov 2010     

Research Associate

Fitzpatrick Institute of Photonics, Duke University electrical and Comp. Engineering dept. Durham , North Carolina, USA

Jun 2006- May 2008

Project Scientist

IIT Delhi, India

Nov 2005 – May 2006

Pre-PhD Experience

 

 

Sen. Research Fellow/Jun. Research  Fellow

IIT, Delhi, India

Oct 2000 – Nov 2005

Research student

Cochin University, Kerala, India

1999 Jul – 2000 Sep
       

 

MEMBERSHIPS

Optical Society of America (OSA)

Optical Society of India (OSI)

Laser and Spectroscopy Society of India (lifetime member) (LASSI)

 

PUBLICATIONS


  1. Renu John, Robabeh Rezaeipoor, Steven G. Adie, Eric J. Chaney, Amy L. Oldenburg, Marina Marjanovic, Justin P Haldar, Brad Sutton, and Stephen A. Boppart, “In vivo Magnetomotive optical molecular imaging using targeted magnetic nanoprobes”, PNAS 107, 8085-8090 (2010).
  2. Renu John, Eric J. Chaney, and Stephen A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography”, IEEE J. Sel. Top. Quant Electron. 16, 691-697, (2010).
  3. Renu John, Freddy T. Nguyen, Kenneth J. Kolbeck, Eric J. Chaney, Marina Marjanovic, Kenneth S. Suslick, Stephen A. Boppart, "Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents" Molecular Imaging in Biol. 3-10 (2011). DOI: 10.1007/s11307-011-0473-7.
  4. Renu John  and  Stephen A. Boppart, “Magnetomotive molecular nanoprobes”,  Current Medicinal Chem. 18, 2103-2114, (2011).
  5. Xing Liang, Steven G. Adie, Renu John, and Stephen A. Boppart, Dynamic spectral domain optical coherence elastography for tissue characterization”, Opt. Exp. 18, 14183-14190 (2010).
  6. Steven G. Adie, Xing Liang, Brendan F. Kennedy, Renu John, David D. Sampson, and Stephen A. Boppart, "Spectroscopic optical coherence elastography," Opt. Exp. 18, 25519-25534 (2010).
  7. Robabeh Rezaeipoor, Renu John, Steven G. Adie, Eric J. Chaney, Marina Marjanovic, Amy L. Oldenburg, Stephanie A. Rinne, Stephen A. Boppart, “Fc-Directed Antibody Conjugation of Magnetic Nanoparticles for Enhanced Molecular Targeting”, J. Innov. Opt. Health Sciences 2, 387–396 (2009).
  8. Haohua Tu, SungHwan Shin, Renu John, and Stephen A. Boppart, “Long-period fiber gratings spontaneously written by a mechanism markedly different from Hill grating formation”, Appl. Phys. Lett. 97, 1-3 (2010). Michael Gehm, Renu John, David J. Brady, Rebecca M. Willet, and Timothy J. Schulz, “Single-shot compressive spectral imaging with a dual-disperser architecture”, Opt. Exp. 15, 14013-14027 (2007).
  9. Ashwin A Wagadarikar, Renu John, Rebecca M. Willet, Timothy J. Schulz, Michael Gehm and David J. Brady, “Snap-shot compressive hyperspectral imaging with single disperser architecture”, Appl. Opt. 47, B44-B51 (2008)  
  10. Shikhar Uttam, Nathan Goodman, Mark Neifeld, Changsoon Kim, Renu John, Jungsang Kim, and David Brady, “Optically multiplexed imaging with superposition space tracking”, Opt. Exp. 17, 1691-1713 (2009). 
  11. Renu John, Joby Joseph, and Kehar Singh “A new balanced-modulation code for phase-image-based holographic data storage system”, J. Opt. A Pure and Appl. Opt. 7, 391-395 (2005).
  12. Renu John, Joby Joseph, and Kehar Singh “Phase-image-based content-addressable holographic data storage with security”, J. Opt. A. Pure and Appl. Opt. 7, 123-128 (2005).
  13. Renu John, Joby Joseph, and Kehar Singh “An input-data page modulation scheme for content-addressable holographic digital data storage”, Opt. Commun, 249, 387-395 (2005).
  14. Renu John, Joby Joseph and Kehar Singh “Content-addressable holographic data storage using hybrid ternary modulation in a Twisted Nematic Liquid Crystal Spatial Light Modulator”, Opt. Rev. 12, 155-160 (2005).
  15. Renu John, Joby Joseph and Kehar Singh “Holographic data storage using phase modulated pixels”, Opt. Lasers. Engg. 42, 183-194 (2005).
  16. Renu John, Joby Joseph and Kehar Singh, “Phase-image-based content-addressable holographic data storage”, Opt. Commun. 232, 99-106, (2004).
  17. Murtaza Ali, Renuka Parlapalli, Renu John, Low power real time signal processing engine for optical coherence tomography systems using multi-core digital signal processor  Proc. SPIE 7889, 78892J, (2011). DOI: 10.1117/12.875523. (Peer reviewed conference proceedings).
  18. Xing Liang, Benedikt W. Graf, Renu John, Vasilica Crecea, Freddy T. Nguyen, Huafeng Ding, Hyon-min Song, Gabriel Popescu, Alex Wei, and Stephen A. Boppart “Magnetomotive optical coherence microscopy for cell dynamics and biomechanics”, Proc SPIE 7889, 788926, (2011), DOI: 10.1117/12.875139. (Peer reviewed conference proceedings).
  19. Nan Zheng, Nathan Hagen, Renu John, and David Brady, “A static multiplex Fabry-Perot spectrometer,” Proc. SPIE 7249, 72490Z (2009). (Peer reviewed conference proceedings).
  20. Ashwin A Wagadarikar, Renu John, Rebecca M. Willet, Timothy J. Schulz, Michael Gehm and David J. Brady, “Single disperser design for snap-shot coded-aperture spectral imaging”, Proc. SPIE 6714 7140A-1-9 (2007). (peer reviewed conference proceedings).

Book chapters

  1. Renu John and Stephen A. Boppart, “Scattering, absorption, and modulating nanoprobes in Nano-Biophotonics, McGraw-Hill, New York, (2010).

International/National Conferences

  1. Renu John, Robabeh Rezaeipoor, Steven G. Adie, Eric J. Chaney, Amy L. Oldenburg, Marina Marjanovic, Brad Sutton, and Stephen A. Boppart, “Magnetomotive optical molecular imaging using targeted magnetic nanoprobes”, Center for nanoscale Science and Technology Annual Workshop, University of Illinois Urbana Champaign, May 6, 7 2010.
  2. Freddy T. Nguyen, Renu John, Eric J. Chaney, Elizabeth M. Dibbern, Kenneth S. Suslick, Stephen A. Boppart, Magnetomotive OCT for targeted cancer imaging with RGD-iron oxide protein microspheres”, Center for nanoscale Science and Technology Annual Workshop, University of Illinois Urbana Champaign, May 6, 7 2010.
  3. Freddy T. Nguyen, Renu John, Eric J. Chaney, Elizabeth M. Dibbern, Kenneth S. Suslick, Stephen A. Boppart, “RGD coated protein microspheres as a dual fluorescent and magnetomotive contrast agent for targeted cancer imaging with magnetomotive optical coherence tomography”, American Association of Cancer Research (AACR) 101th annual meet, April 17-21, 2010.
  4. Renu John, Robabeh Rezaeipoor, Steven G. Adie, Eric J. Chaney, Amy L. Oldenburg, Marina Marjanovic, Brad Sutton, and Stephen A. Boppart, “Magneto-motive optical coherence tomography for ultrasensitive and molecular specific in vivo imaging of mammary tumors using targeted magnetic nanoprobes”, SPIE Photonics West San Franscisco, California, Jan 26-28, 2010.
  5. Renu John, Freddy T. Nguyen, Eric J. Chaney, Marina Marjanovic, Kenneth Suslick and  Stephen A. Boppart, “Targeted Multi-Functional Multi-Modal Microspheres as Optical Contrast Agents for Cardiovascular Disease and Cancer”, SPIE Photonics West San Franscisco, California, Jan 26-28, 2010.
  6. Jeehyun Kim, Unsang Jung, Mansik Jeon, Junghwan Oh, Woonggyu Jung, Renu John, Vasilica Crecea, and Stephen A. Boppart, “Forward Focused Scanning Magneto-Motive Optical Doppler Tomography”,  SPIE Photonics West San Franscisco, California, Jan 26-28, 2010.
  7. Renu John, Vasilica Crecea, Eric Chaney and Stephen A. Boppart, “Tracking dynamics of magnetic nanoparticle-based contrast agents in tissues using magnetomotive optical coherence tomography”, Advances in Optics for Biotechnology, Medicine and Surgery XI, Jun 28-Jul 01, Vermont, USA (2009).
  8. Nan Zheng, Nathan Hagen, Renu John, and David Brady, “A static multiplex Fabry-Perot spectrometer,” Photonics West, Jan 26-29 2009, San Jose USA.
  9. Renu John, David J. Brady, Rebecca M. Willet, Michael Gehm and Timothy J. Schulz, “A snap-shot dual disperser for compressive hyperspectral imaging”, Frontiers in Optics 2007, Sept 16-20, California, USA.

10.  Ashwin A Wagadarikar, Renu John, Rebecca M. Willet, Timothy J. Schulz, Michael Gehm and David J. Brady, “Single disperser design for snap-shot coded-aperture spectral imaging”, Optics and Photonics 2007, Aug 26-30, San Diego California, USA, Proc. SPIE 6714 (2007).

11.  David J. Brady, Michael Gehm, Timothy J. Schulz, Renu John, and Rebecca M. Willet, “Optical designs for compressive single-shot spectral imaging”, Computational Optical sensing and imaging, Vancouver, Canada, Jun 18-20 (2007).

12.  Rebecca M. Willet, David J. Brady, Michael Gehm and Renu John, “Compressive spectral imaging and multiscale reconstruction methods”, Computational Optical sensing and imaging, Vancouver, Canada, Jun 18-20 (2007).

13.  Michael Gehm, Andrew Portnoy, Andrew Fontanella, Renu John, David J. Brady, Rebecca M. Willet and Timothy J. Schulz, “Dual disperser design for single shot computational spectral imaging”, Frontiers in Optics 2007, Oct 8-12,  Rochester, New York, USA.

14.  Renu John, Joby Joseph, and Kehar Singh, “Improving content-addressability in a holographic database using new input modulation schemes”, Conference of Lasers and Electro-Optics CLEO 2005, May 22-27, 2005, Baltimore, Maryland USA.

15.  Renu John, Joby Joseph, and Kehar Singh, “Improving content-addressability of holographic memories”, International conference on optics and optoelectronics (ICOL 2005), Dec 12-15, 2005, Dehradun, India.

16.  Joby Joseph, Renu John and Kehar Singh, “A novel input addressing technique for a content-addressable holographic memory”, International conference on optics and optoelectronics (ICOL 2005), Dec 12-15, 2005, Dehradun, India.

17.  Renu John, Joby Joseph, and Kehar Singh, “Phase-image-based content-addressable holographic data storage with security” I2TECH 2005, Exhibition of IIT Delhi Technologies, April 23, 2005.

18.  Renu John, Joby Joseph, and Kehar Singh, “A new balanced-modulation code for phase-image-based holographic data storage system”, XXX Optical Society of India (OSI) Symposium on Optics and Opto-Electronics (SOOP-05) Jan 19-21, 2005.

19.  Renu John, Joby Joseph, and Kehar Singh, “A novel input page modulation scheme for content-addressable holographic data storage”, Photonics Asia 2004 Nov.11-15, Beijing, China.

20.  Renu John, Joby Joseph, and Kehar Singh “Content-addressable holographic data storage with security”, Photonics 2004, Dec 11-15, CUSAT, Kochi, India.

21.  Renu John, Joby Joseph, and Kehar Singh, “A modulation scheme for content-addressable holographic data storage,” Photonics 2004, Dec 11-15, CUSAT, Kochi, India.

22.  Renu John, Joby Joseph and Kehar Singh, “Phase image based content addressable holographic database using Lithium Niobate crystal”, Ninth International Conference on Photorefractive Effects, Materials and Devices, La Colle sur Loup, Nice, France June 17-21 2003.

23.  Renu John, Joby Joseph and Kehar Singh, “Content-addressable digital holographic data storage using hybrid ternary modulations in a twisted-nematic liquid crystal spatial light modulator”, International Conference on Laser Applications and Optical Metrology, ICLAOM-03, Delhi, India, IIT Dec 1-4 2003.

24.  Renu John, Naveen Kumar Nishchal and Kehar Singh, “Optical data security and holographic data storage”, International Conference on Laser Applications and Optical Metrology, ICLAOM-03, Delhi, India, IIT Dec 1-4 2003.

25.  Reshmi C., Renu John, Joby Joseph, and Kehar Singh, “Bit-error rate studies of a modulation coded holographic database,” in Nat’l Confer. on Perspectives in Engineering Optics and Spectroscopy (NCPEOS’04) April 5-7, 2004, C. C. S. Univ. Meerut, India.

26.  Renu John, Joby Joseph, and Kehar Singh, “Improvement of discrimination capability of content addressable holographic storage using hybrid ternary modulation,” in Nat’l Confer. on Perspectives in Engineering Optics and Spectroscopy (NCPEOS’04) April 5-7, 2004, C. C. S. Univ. Meerut, India.

27.  Renu John, Joby Joseph and Kehar Singh, “ Content addressable holographic memory using shift multiplexing.”, 28th Optical Society of India, Conference on Optics and Photonics in Engineering (COPE-03) Netaji Subhas Institute of Technology Delhi January 6-8  2003.

28.  Renu John, Joby Joseph and Kehar Singh, “Phase image based holographic data storage”, to be presented in 28th Optical Society of India, Conference on Optics and Photonics in Engineering (COPE-03) Netaji Subhas Institute of Technology Delhi January 6-8 2003.

29.  Renu John, Joby Joseph and Kehar Singh, “Phase image based holographic data storage for digital data,” National Conference on Lasers and Spectroscopy, Meerut college, Meerut, India, February 25-28, 2003.

30.  Renu John, Joby Joseph and Kehar Singh, “Phase image based content addressable holographic memory for improved discrimination between data pages using random phase mask.”, National Conference on Lasers and Spectroscopy, Meerut college, Meerut, India  February 25-28, 2003.

31.  Renu John, Joby Joseph and Kehar Singh, “Holographic data storage system using out-of-plane angular multiplexing in reflection geometry.”, in  National symposium on frontiers in condensed matter physics (NSFCMP ’02) March 22-23 2002 Guru Jambheswar University, Hisar, Haryana, India.

32.  Renu John, Joby Joseph and Kehar Singh, “Holographic data storage using angular multiplexing”, in National conference on lasers and spectroscopy. Dec 28-31, 2001, Ch. Charan Singh University, Meerut.

Press coverage

Press coverage on my work published in PNAS, April 2010

In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes PNAS 107 8085-8090 (2010)

  • “Magnetism puts nanoparticles on the move :”, Coverage by www. futurity.org

http://futurity.org/science-technology/magnetism-puts-nanoparticles-on-the-move/

  • New Imaging Method uses Magnetic Nanoparticles that Move, Beckman News letter April 2010

http://www.beckman.illinois.edu/news/Boppart042610

  • In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes OCTNEWS 2010

http://www.octnews.org/articles/1972825/in-vivo-magnetomotive-optical-molecular-imaging-us/

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