Everyone likes to point the blame of tragic events on certian characters. I am here to map out the blame so that you can more accurately blame the right person. Name in [ ] is the Event-Instigator. Hover names for a blurb.

Fred's Death
Angel > Gunn > [Knox]

Conner's Weirdness i.e. Kidnap
Holtz > Wesley > Holtz > Sahjhan

Cordy's Death (and Conner/Cordy Grossness)
Jasmine > Lorne > Skip > [Higher Powers]
> Conner > [Sahjhan]
Note: If you are looking for a character to target go for Skip