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Garry Nolan Page
* I obtained my first university degree from the Damascus university (Damascus, Syria).
* I have obtained my Ph.D from the Karolinska Institute (Stockholm, Sweden).
* I was a ressearch fellow (2000-2002) at the National Cancer Institute , NIH (Bethesda, MD, USA).
* I am currently a staff scientist in the Max-Delbruck-Center for Molecular Medicine. (Berlin, Germany)
2. Gene therapy.
3. Immunity to viral and bacterial infections.
4.Natural killer (NK) cells biology.
5. DNA vaccines.
6. In vivo imaging.
1: Charo J, Lindencrona JA, Carlson LM, Hinkula J, Kiessling R.
Protective efficacy of a DNA influenza virus vaccine is markedly increased by the coadministration of a Schiff base-forming drug. J Virol. 2004 Oct;78(20):11321-6.
2: Roos AK, Pavlenko M, Charo J, Egevad L, Pisa P.
Induction of PSA-specific CTLs and anti-tumor immunity by a genetic prostate cancer vaccine. Prostate. 2004 Jun 25 [Epub ahead of print]
3: Kurte M, Lopez M, Aguirre A, Escobar A, Aguillon JC, Charo J, Larsen CG, Kiessling R, Salazar-Onfray F.
A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells. J Immunol. 2004 Aug 1;173(3):1731-7.
4: Choudhury A, Charo J, Parapuram SK, Hunt RC, Hunt DM, Seliger B, Kiessling R.
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines. Int J Cancer. 2004 Jan 1;108(1):71-7.
5: Charo J, Sundback M, Wasserman K, Ciupitu AM, Mirzai B, van der Zee R, Kiessling R.
Marked enhancement of the antigen-specific immune response by combining plasmid DNA-based immunization with a Schiff base-forming drug.Infect Immun. 2002 Dec;70(12):6652-7.
6: Ciupitu AM, Petersson M, Kono K, Charo J, Kiessling R.
Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses. Cancer Immunol Immunother. 2002 May;51(3):163-70.
7: Charo J, Geluk A, Sundback M, Mirzai B, Diehl AD, Malmberg KJ, Achour A, Huriguchi S, van Meijgaarden KE, Drijfhout JW, Beekman N, van Veelen P, Ossendorp F, Ottenhoff TH, Kiessling R.
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65. Eur J Immunol. 2001 Dec;31(12):3602-11.
8: Leifert JA, Lindencrona JA, Charo J, Whitton JL.
Enhancing T Cell Activation and Antiviral Protection by Introducing the HIV-1 Protein Transduction Domain into a DNA Vaccine.
Hum Gene Ther. 2001 Oct 10;12(15):1881-92.
9: Charo J, Sundback M, Geluk A, Ottenhoff T, Kiessling R.
Dna immunization of hla transgenic mice with a plasmid expressing mycobacterial heat shock protein 65 results in hla class i- and ii-restricted t cell responses that can be augmented by cytokines.
Hum Gene Ther. 2001 Sep 20;12(14):1797-804.
PMID: 11560772 [PubMed - in process]
10: Geberhiwot T, Assefa D, Kortesmaa J, Ingerpuu S, Pedraza C, Wondimu Z, Charo J, Kiessling R, Virtanen I, Tryggvason K, Patarroyo M.
Laminin-8 (alpha4beta1gamma1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation.
J Cell Sci. 2001 Jan;114(Pt 2):423-33.
11: Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, Kiessling R, Jornvall H, Wigzell H, Gudmundsson GH.
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations.
Blood. 2000 Nov 1;96(9):3086-93.
12: Wilson JL, Heffler LC, Charo J, Scheynius A, Bejarano MT, Ljunggren HG.
Targeting of human dendritic cells by autologous NK cells.
J Immunol. 1999 Dec 15;163(12):6365-70.
13: Charo J, Ciupitu AM, Le Chevalier De Preville A, Trivedi P, Klein G, Hinkula J, Kiessling R.
A long-term memory obtained by genetic immunization results in full protection from a mammary adenocarcinoma expressing an EBV gene.
J Immunol. 1999 Dec 1;163(11):5913-9.
14: Wilson JL, Charo J, Martin-Fontecha A, Dellabona P, Casorati G, Chambers BJ, Kiessling R, Bejarano MT, Ljunggren HG.
NK cell triggering by the human costimulatory molecules CD80 and CD86.
J Immunol. 1999 Oct 15;163(8):4207-12.
15: Rongcun Y, Salazar-Onfray F, Charo J, Malmberg KJ, Evrin K, Maes H, Kono K, Hising C, Petersson M, Larsson O, Lan L, Appella E, Sette A, Celis E, Kiessling
Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas.
J Immunol. 1999 Jul 15;163(2):1037-44.
16: Kono K, Rongcun Y, Charo J, Ichihara F, Celis E, Sette A, Appella E, Sekikawa T, Matsumoto Y, Kiessling R
Identification of HER2/neu-derived peptide epitopes recognized by gastric cancer-specific cytotoxic T lymphocytes.
Int J Cancer. 1998 Oct 5;78(2):202-8.
17: Petersson M, Charo J, Salazar-Onfray F, Noffz G, Mohaupt M, Qin Z, Klein G, Blankenstein T, Kiessling R.
Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1.
J Immunol. 1998 Sep 1;161(5):2099-105.
18: Salazar-Onfray F, Charo J, Petersson M, Freland S, Noffz G, Qin Z, Blankenstein T, Ljunggren HG, Kiessling R.
Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.
J Immunol. 1997 Oct 1;159(7):3195-202.
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