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Frederic Woringer: Pautrier-Woringer disease (lipomelanotic reticulosis/dermatopathic lymphadenitis).
Steffen C.
This historical perspective will introduce Frederic Woringer and review the original article by Lucien-Marie Pautrier and Woringer on Pautrier-Woringer disease (reticulose lipo-melanique, lipomelanotic reticulosis, dermatopathic lymphadenitis). The current status of dermatopathic lymphadenitis is synopsized.
Publication Types:
- Biography
- Historical Article
Personal Name as Subject:
PMID: 15618933 [PubMed - indexed for MEDLINE]
Comment in:
Fine needle aspiration cytology of dermatopathic lymphadenitis.
Iyer VK, Kapila K, Verma K.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
OBJECTIVE: To delineate and describe the cytomorphologic features of dermatopathic lymphadenitis on fine needle aspirated material. STUDY DESIGN: Thirteen cases of previously diagnosed dermatopathic lymphadenitis (DLN) and 10 cases of reactive lymphadenitis (RLN) (5 each of sinus histiocytosis and follicular hyperplasia) were reexamined by two independent observers. The cytologic features were semiquantitated (0-3+). Histology was available in two cases. RESULTS: A variable amount of melanin pigment was seen in all 13 cases of DLN and in only 3 cases of RLN. DLN had large histiocytic collections with blood vessels at the center (12/13). The histiocytic cells had an elongated nucleus (13/13) with nuclear grooves (13/13) and pseudonucleoli (11/13). Many of these nuclei had a convoluted and crumpled appearance (11/13). On immunocytochemistry these cells were S-100 positive (six cases) and CD68 negative (one case). In contrast, in RLN with sinus histiocytosis, the histiocytes were polygonal and had rounded nuclei. Spindle-shaped histiocytes were rare, while pseudonucleoli and nuclear grooves were absent. Sinus histiocytes were CD68 positive and S-100 negative on histologic sections. Tingible body macrophages were rare (2/13) in DLN and prominent (8/10) in RLN. Mitoses were seen in DLN (6/13) and RLN (9/10). CONCLUSION: The morphologic features found to be helpful in the diagnosis of DLN on fine needle aspiration cytology are melanin-laden macrophages with variable pigment; large, histiocytic clusters with blood vessels at the center; characteristic histiocytes, with elongated vesicular nuclei, nuclear grooves, crumpled and convoluted nuclei and pseudonucleoli; and absence of or very few tingible body macrophages. Positivity on immunostaining for S-100 and negativity for CD68 aid in the diagnosis.
PMID: 9850641 [PubMed - indexed for MEDLINE]
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