Uterine cervix: ASC-H (cannot exclude HSIL)


Drs. Prolla and Diehl's INTERESTING CASE OF THE MONTH December 2002 case B answer

Papanicolaou staining, groups of spindle shaped parabasal cells.

Papanicolaou staining, some small hyperkeratotic cells are present

Papanicolaou staining

Papanicolaou staining, there is one cell with a bizarre shape but with a nucleus with normal looking chromatin.

The smear shows abnormal squamous cells in a hypotrophic postmenopausal pattern. There are groups of spindle shaped parabasal cells. Some small hyperkeratotic cells are also present. There is one cell with a bizarre shape but with a nucleus with normal looking chromatin. Clean background with very few inflammatory cells or debris. These findings suggested the diagnosis of ASC-H in a hypotrophic smear. The clinician ordered a colposcopy, that revealed only an atrophic cervix, and a Hybrid Capture 2 test, that was negative for HPV DNA. This management is still controversial: read the abstracts on ASC-US and ASC-H management. A follow up smear taken one year later was entirely normal.



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