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FNA of liver with multiple nodules, 62-year old male with lung neoplasm
The FNA smears show the typical features of small cell carcinoma: single small cells, with some loose groups showing nuclear molding, DNA streaking. The nuclei are oval or angulated, with "salt and pepper" chromatin, small or absent nucleoli. The cytoplasm is scant or absent.
Features of Small cell carcinoma
Cellular patterns:
Three-dimensional loose groups of small cells, with high N/C ratio
Cell within cell pattern
Occasional tandem or indian file cell pattern
Cytoplasm:
Small rim of basophilic cytoplasm or naked nuclei
Nucleus
Round or angular hyperchromatic, "oat cell" type
Few small or absent nucleoli
Some cases have a large nucleolus: "intermediate cell" type
"Salt and pepper" chromatin, with nuclear molding
Mitoses, karyorrhexis and apoptotic bodies("blue bodies") are frequent
DNA streaking or nuclear smudging
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See also Case B
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