The presence of large multinucleated cells, with ground glass type of chromatin, and marginal condensation of chromatin is typical of Herpes simplex virus or varicella zoster virus cytopathic effects. Perirectal and perineal ulcerations from HSV2 are a common opportunistic infection in AIDS patients. Enzyme immunoassay for HSV was positive. This patient was HIV positive, and responded well to acyclovir oral therapy.
See also Case A
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