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Items 1-15 of 15 |
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One page. |
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Metastatic laryngeal basaloid squamous cell carcinoma simulating primary small cell carcinoma of the lung on fine needle aspiration lung biopsy. A case report.
Vesoulis Z.
Department of Pathology, Akron City Hospital (Summa Health Systems), Ohio 44309, USA.
BACKGROUND: First described in 1986, the basaloid squamous variant of laryngeal carcinoma is an uncommon, aggressive neoplasm with early presentation of metastatic disease and widespread dissemination. It is characterized primarily by its biphasic morphologic appearance. CASE: A 64-year-old female smoker presented with left hilar and right lower lung lobe masses. The fine needle aspiration cytologic findings were consistent with features of primary undifferentiated small cell carcinoma. CONCLUSION: The basaloid squamous cell carcinoma of head and neck region is a highly malignant neoplasm with frequent metastatic disease at the time of diagnosis. Metastatic deposits may consist of basaloid and/or squamous carcinoma cells. The basaloid component of this biphasic neoplasm is poorly differentiated and demonstrates cytologic features that mimic undifferentiated small cell carcinoma. Previous reports of cervical lymph node metastases from basaloid squamous carcinoma indicate frequent misdiagnosis as small cell carcinoma. Pulmonary metastases are more problematic since they introduce the possibility of a second primary lesion in these patients who have a frequent history of cigarette and/or ethanol abuse. Immunohistochemistry is useful in the distinction of metastatic basaloid squamous carcinoma from a second primary cell carcinoma of the lung.
PMID: 9622708 [PubMed - indexed for MEDLINE]
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Comparison of the sensitivity of sputum and brush cytology in the diagnosis of lung carcinomas.
Sing A, Freudenberg N, Kortsik C, Wertzel H, Klosa B, Hasse J.
Department of Pathology, Albert-Ludwigs-Universitat, Freiburg, Germany.
OBJECTIVE: To describe the role of sputum and brush cytology in the diagnosis of lung carcinoma and to elucidate the influence of tumor location, histologic tumor type and stage on the sensitivity of both methods. STUDY DESIGN: Retrospective and performed on 415 lung cancer patients. Two hundred of them were investigated only by sputum collection, 119 only by brushing and 96 by both methods. RESULTS: The overall sensitivity of the sputum technique was 0.403 and that of the brush method 0.500, while a combination of both showed a sensitivity of 0.640. The diagnostic yield depended on tumor location, histologic tumor type and stage. Sputum specimens were most valuable in the detection of early and peripheral carcinomas, whereas brushing was superior in finding more advanced and centrally located malignancies. Regarding tumor type, squamous cell carcinomas were diagnosed to the greatest extent by both methods. CONCLUSION: A complementary role of both cytologic techniques can be postulated by our data as well as by a literature review.
Publication Types:
PMID: 9100773 [PubMed - indexed for MEDLINE]
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Cystic change in lymph nodes with metastatic squamous cell carcinoma.
Verma K, Mandal S, Kapila K.
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
A retrospective analysis was performed of the gross characteristics of aspirated material in 335 consecutive cases of metastatic squamous cell carcinoma in cervical/supraclavicular lymph nodes seen during a three-year period. In 57 cases (17.01%), 1-2 mL of fluid was obtained. Microscopic examination of cytocentrifuge smears in all cases showed malignant squamous cells. Cystic change in lymph nodes harboring metastatic squamous cell carcinoma was frequently associated with a tongue primary (21/58 cases, 36.2%) followed by an esophageal primary (4/16 cases, 25%). The frequency of cystic change varied from 9.1% to 21.5% with primaries in the oral cavity, nasopharynx, lung, uterine cervix and unknown sites.
PMID: 7762335 [PubMed - indexed for MEDLINE]
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Cytologic features of peripheral squamous cell carcinoma of the lung.
Kamiya M, Uei Y, Shimosato Y.
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Cytologic features of 32 peripheral squamous cell carcinomas of the lung were reviewed. Fine needle aspiration biopsy and curettage showed most of the tumor cells to be arranged in irregular cell fragments consisting of relatively small cells with scanty cytoplasm. They possessed round to oval nuclei with coarsely granular chromatin, and some had large, prominent nucleoli. Keratinization was usually observed in small numbers of scattered cells, and a nuclear streaming arrangement was noted in some areas. When both keratinization and streaming arrangements were absent, correct subtyping was impossible (12 cases). These cytologic features were different from those of 31 hilar squamous cell carcinomas studied as controls; there many carcinoma cells showed keratinization, and small carcinoma cells were infrequent. However, in all cases, sputum cytology was correctly interpreted because squamous differentiation was easily recognized.
PMID: 7847010 [PubMed - indexed for MEDLINE]
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Widespread posttracheostomy atypia simulating squamous cell carcinoma. A case report.
Berman JJ, Murray RJ, Lopez-Plaza IM.
Cytology Section, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21218.
Squamous atypia appears as a benign posttracheostomy phenomenon occasionally mistaken for squamous carcinoma. Most often seen are clumps of atypical metaplastic cells with irregular nuclear rims and chromatin that can be either finely dispersed or coarsely clumped. The cytoplasm is thick, and the cytoplasmic membrane is sharply outlined. We describe a case of squamous atypia occurring in a patient 30 years after laryngectomy. The atypia was so extreme that segmental bronchoscopy was performed to search for occult carcinoma. No carcinoma was found, but numerous atypical cells were found in the segmental bronchi sampled by endobronchial brushings. This finding indicates that posttracheostomy atypia can involve respiratory mucosa distant from the tracheal (stump) mucosa. Sputum and bronchoscopic samples received from patients with tracheostomies should be screened with a clear understanding of the morphologically distinct atypia encountered.
PMID: 1950320 [PubMed - indexed for MEDLINE]
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Cells of squamous cell carcinoma in pleural, peritoneal and pericardial fluids. Origin and morphology.
Smith-Purslow MJ, Kini SR, Naylor B.
Department of Pathology, Henry Ford Hospital, Detroit, MI 48202.
The records of two cytopathology laboratories, covering an aggregate of 33 years, were searched for pleural, peritoneal and pericardial fluids reported as containing cells of squamous cell carcinoma (SCC). This search embraced 9,297 serous fluids from 7,389 patients. Cells of SCCs were found in the fluids from only 46 patients, illustrating the infrequency of such a finding, with most of the SCC cells originating in primary neoplasms of the lung (16), female genital tract (8) or larynx (6). All of the recognized types of SCC cells were found in these fluids. Even so, SCC cells may be mistaken for cells of other neoplasms, such as adenocarcinoma and malignant mesothelioma. SCC cells in serous fluids should be identifiable if careful attention is paid to the morphologic features characteristic of SCC.
PMID: 2467481 [PubMed - indexed for MEDLINE]
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Differences in cytomorphologic features between central and peripheral squamous cell carcinomas of the lung.
Miyamoto H, Araya Y, Isobe H, Dosaka H, Endo T, Kawakami Y.
Publication Types:
PMID: 3421021 [PubMed - indexed for MEDLINE]
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Histologic and cytologic patterns of lung cancer in 2,580 men and women over a 15-year period.
Johnston WW.
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710.
This paper describes the relative frequencies and changes in the morphologic patterns of lung cancer, as documented in the histologic and cytologic specimens from 2,580 patients diagnosed and treated at Duke University Medical Center over a period of 15 consecutive years. During the first five years, the relative frequencies of the various types of lung cancers were, in descending order, squamous cell carcinoma (43.1%), large cell undifferentiated carcinoma (22.5%), adenocarcinoma of the acinar type (18.6%), small cell undifferentiated carcinoma (11.6%), bronchioloalveolar carcinoma (3.5%) and adenosquamous carcinoma (0.7%). During the second and third five-year periods, squamous cell carcinoma remained the most common neoplasm, but declined to 35.7%, while adenocarcinoma of the acinar type became the second most common lung cancer at 22.0%. The absolute and relative incidences of lung cancer in women showed a striking increase from 21.8% to 29.9%. During this same period, adenocarcinoma of the acinar type replaced squamous cell carcinoma as the most common primary lung cancer in women.
PMID: 2831686 [PubMed - indexed for MEDLINE]
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Cytologic and histologic correlation in primary lung cancer. A study of 154 cases with resectable tumors.
Tanaka T, Yamamoto M, Tamura T, Moritani Y, Miyai M, Hiraki S, Ohnoshi T, Kimura I.
The accuracy of cytologic diagnosis and typing was examined in 154 patients, 113 males and 41 females, who underwent radical surgery during the past six years. There were 42 central and 112 peripheral lesions: 6 adenocarcinomas and 28 squamous-cell carcinomas were centrally located and 69 adenocarcinomas and 27 squamous-cell carcinomas were peripherally located. Repetition of sputum sampling at least three times was preferred, especially in central lesions, which were detected in 57% to 64% of the cases by either three-day-pooled or aerosol-induced specimens. Peripheral lesions required brushing to enhance the accuracy. The overall typing accuracy was 64.3%, ranging from 83.6% in squamous-cell carcinoma to 25.0% in large-cell carcinoma. Cytologic positivity correlated well with the finding of tumors more than 3 cm in diameter. Adenocarcinoma and squamous-cell carcinoma showed no significant difference in frequency of regional lymph nodal metastases. The value of judging the accuracy of cytologic diagnosis and typing on the histologic evaluation of the entire resected lesion, rather than on biopsy specimens, is emphasized.
PMID: 3881879 [PubMed - indexed for MEDLINE]
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Primary cytodiagnosis of synchronous small-cell cancer and squamous-cell carcinoma of the respiratory tract.
Willett GD, Schumann GB, Genack L.
Report is made of the first primary cytodiagnosis of a synchronous small-cell cancer of the lung and squamous-cell carcinoma of the larynx, which were histologically confirmed. Sputum cytology should be used in the detection and surveillance of multiple primary malignancies of the respiratory tract, which have been observed with increasing frequency.
PMID: 6207696 [PubMed - indexed for MEDLINE]
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Cytologic diagnosis of pulmonary carcinoma on bronchoscopic brushing material.
Pilotti S, Rilke F, Gribaudi G, Spinelli P.
The material obtained by brushing procedures under visual control from 370 consecutive patients with histologically confirmed primary carcinoma of the lung who underwent bronchoscopy was examined cytologically. The sputum of 276 of these patients was also investigated. The overall sensitivity of the bronchoscopically obtained cytology was 0.67; however, the values were 0.78 and 0.28, respectively, for the cases with and without visible lesions of the bronchi. Sputum examination enhanced the sensitivity to 0.79 overall and to 0.84 and 0.61, respectively, for the two groups, with a greater benefit for the group with negative bronchoscopy. The overall cytologic typing accuracy for 252 cases was 0.66, with a range of 0.19 to 0.86, depending on the histologic type. Typing failures were essentially related to adenocarcinomas and large-cell carcinomas.
PMID: 6293231 [PubMed - indexed for MEDLINE]
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Ten years of respiratory cytopathology at Duke University Medical Center. II. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, with a comparison between cytopathology and histopathology in the typing of lung cancer.
Johnston WW, Bossen EH.
In 1975 Duke University Medical Center, a retrospective and prospective survey of respiratory cytopathologic specimens was undertaken for the ten-year period 1970 to 1979. The purpose of this study was to document the role of cytopathology in the diagnosis of lung cancer at this institution. This paper presents the results of the cytopathologic and histopathologic typing of cases of lung cancer seen at Duke University Medical Center from 1970 to 1974. During this period, 9,892 cytologic specimens from the lower respiratory tract were processed. Cytopathologic diagnoses of cancer with tissue confirmation were made on 483 specimens from 232 patients. Because original cytologic diagnoses, but not histopathologic diagnoses, had been made in conformity with a modified WHO classification of lung neoplasms, all histopathologic material was reviewed and reclassified when necessary. This was carried out by one of the authors (E.H.B.) as a blind review without benefit of knowledge of either preexisting cytopathologic or histopathologic diagnoses. Twenty-six patients were excluded from the current study because of lack of satisfactory histologic material. In 94 patients classified by histopathology as having squamous cell carcinoma, 76.4% of the positive cytologic specimens were also called squamous cell carcinoma; 18.6% were interpreted as large cell undifferentiated carcinoma. In 39 patients classified by tissue as having large cell undifferentiated carcinoma, the cytology agreed in 42.4% of the positive specimens. For the 29 patients thought histologically to have small cell undifferentiated carcinoma, the same diagnosis was rendered in 95.5% of the cytologically positive specimens from these patients. For the adenocarcinoma group of 43 patients, a cytopathologic diagnosis of adenocarcinoma was made in 67.8% of the positive specimens.
PMID: 6269341 [PubMed - indexed for MEDLINE]
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The diagnostic reliability of cytologic typing in primary lung cancer with a review of the literature.
Suprun H, Pedio G, Ruttner JR.
To evaluate the growing tendency in recent years to attribute more diagnostic reliability to cytologic methods, we investigated the accuracy of cytologic typing in specimens obtained from bronchopulmonary material by five different clinical sampling methods, comparing the cytologic diagnoses with the known histologic diagnoses. The study consisted of 232 cytologic specimens from 157 cases of primary lung cancer. Of the 232 specimens, 173 (75%) were correctly typed and 59 (25%) incorrectly typed with respect to the appropriate histologic diagnoses. When all sampling methods were considered together, the study demonstrated that well-differentiated epidermoid carcinoma and "oat cell" and spindle-polygonal anaplastic carcinomas yielded high cytologic typing accuracies. In poorly differentiated tumors, bronchioloalveolar cell carcinoma and bronchogenic adenocarcinoma, the correct cytologic typing was much lower. The different tumor types and their degrees of differentiation seem to be the decisive factors in cytologic typing accuracy. The findings of this study were compared with those of others and were found to be consistent with the results of even larger series of cases. For some types the typing accuracy was higher than that reported in other series, whereas for other types, e.g., adenocarcinomas, it was lower.
Publication Types:
PMID: 6255714 [PubMed - indexed for MEDLINE]
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Diagnosis of bronchogenic carcinoma through the cytologic examination of sputum, with special reference to tumor typing.
Gagneten CB, Geller CE, Del Carmen Saenz M.
The results obtained in the cytologic study of sputa from 630 patients are presented. There were 251 cases of bronchogenic carcinoma; diagnosis through sputum examination was possible in 57.4 per cent of the patients. Abnormal cells were detected in an additional 24.3 per cent. Sputum examination has proven to be a valuable complement by establishing the correct diagnosis when other methods failed. Cancer cells were unequivocally identified in 45.8 per cent of the cases with normal bronchoscopic examination and in 52.4 per cent of the cases in which bronchial biopsy did not include malignant tissue. The same proportion of cases with the various tumor types was obtained by cytologic and by histologic study. However, one of the methods often showed a higher degree of cellular differentiation than the other. The number of cases with undifferentiated cancer or unclassified tumors was markedly reduced when the information concerning cell differentiation available through both methods was used. In this manner, excluding the oat cell carcinomas, only 7.6 per cent of the cases of bronchogenic carcinoma did not show any cellular differentiation. The authors recommend wider use of the information provided by simultaneous evaluation of both cytologic smears and tissue sections in order to achieve a more accurate appraisal of tumor type.
PMID: 186996 [PubMed - indexed for MEDLINE]
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Reliability of cytologic typing of lung cancer.
Kanhouwa SB, Matthews MJ.
In a prospective study of 111 cases of lung cancer, cytopathologic diagnoses were compared with histologic diagnoses. In 77.5 per cent of the cases, histopathologic diagnoses were in concurrence with cytopathologic diagnoses. The discrepancies occurred mainly in poorly differentiated adeno and epidermoid carcinoma. Well differentiated adeno and epidermoid carcinoma were cell typed with 100 per cent accuracy and small cell carcinoma with 90 per cent accuracy.
PMID: 1064273 [PubMed - indexed for MEDLINE]
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Items 1-15 of 15 |
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One page. |
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