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Items 1-21 of 21 |
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Pulmonary carcinoid with papillary structure: report of a case with fine-needle aspiration cytology.
Evans H, Blaney R.
Department of Pathology, Lee Hospital, Johnstown, PA 15901-1694.
Fine-needle aspiration biopsy of a peripheral lung mass in a 44-yr-old man revealed a papillary tumor. Histologic examination of the mass, removed by lobectomy, demonstrated a pulmonary carcinoid tumor with papillary structure. Most papillary tumors of the lung are malignant. Pulmonary carcinoid and pulmonary sclerosing hemangioma--benign tumors--have papillary variants. Both have been described in fine-needle aspiration specimens and should be included in the differential diagnosis of papillary lung tumors. The cytologic features of pulmonary carcinoid are described.
PMID: 7813368 [PubMed - indexed for MEDLINE]
Comment in:
Carcinoids, atypical carcinoids, and small-cell carcinomas of the lung: differential diagnosis of fine-needle aspiration biopsy specimens.
Szyfelbein WM, Ross JS.
Department of Pathology, Harvard Medical School, Boston, MA.
The acceptance of fine-needle aspiration biopsy in the diagnostic work-up of pulmonary masses has resulted in an increased number of neuroendocrine tumors of the lung first encountered as aspiration cytology specimens. The accurate cytologic identification of these neuroendocrine neoplasms is important in that they have relatively specific clinical and prognostic features in contrast to nonneuroendocrine neoplasms. We report on the cytologic features of 46 primary pulmonary neuroendocrine neoplasms initially encountered on fine-needle aspiration biopsies. The neoplasms are separated into three distinct cytologic groups, including the typical carcinoid (13 cases), the atypical carcinoid (3 cases), and small-cell carcinomas (30 cases). The clinical features of all cases--and histologic findings when they were available--are also considered. Finally, a detailed cytologic description of the three groups of neuroendocrine neoplasms is presented with emphasis on differential diagnosis including nonneuroendocrine pulmonary neoplasms.
PMID: 2837371 [PubMed - indexed for MEDLINE]
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Carcinoid tumors of the lung: cytologic differential diagnosis in fine-needle aspirates.
Kim K, Mah C, Dominquez J.
Pulmonary carcinoid tumors presenting as peripheral or coin lesions are rare and radiologically may resemble other primary or metastatic neoplasms in the lung. This study consisted of the cytologic evaluation of fine-needle aspirates from five peripheral carcinoid tumors of the lung with particular reference to the differences between the cytologic manifestations of this neoplasm and of small-cell carcinoma and well-differentiated adenocarcinoma. Aspirates of typical carcinoid tumors are characterized by isolated cells and loose aggregates of cells; spindle- and oval-shaped cells of uniform size with scanty, pale eosinophilic cytoplasm; and nuclei with evenly dispersed finely granular chromatin and usually prominent single micronucleoli with occasional macronucleoli. In contrast, the cells of small-cell carcinoma are pleomorphic and arranged in noncohesive loose aggregates, their cytoplasm is scanty, and they show nuclear molding. Their nuclei are hyperchromatic with fine to coarsely granular chromatin. The cells of well-differentiated adenocarcinoma are arranged in three-dimensional clusters or loose aggregates of relatively uniform cells with a columnar configuration. The nuclei are uniformly round and hyperchromatic with finely granular chromatin. Macronucleoli are usually prominent. This study demonstrates that cytologic analysis of fine-needle aspirates can play a significant role in the evaluation and management of peripheral lung tumors.
PMID: 3024938 [PubMed - indexed for MEDLINE]
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Cytopathology of oncocytic carcinoid tumor of the lung mimicking granular cell tumor. A case report.
Ogino S, al-Kaisi N, Abdul-Karim FW.
Department of Pathology, University Hospitals of Cleveland, Ohio, USA.
BACKGROUND: The cytopathologic features of oncocytic carcinoid tumor of the lung, a rare variant of carcinoid tumor that is composed exclusively of oncocytes, have not been described before in detail. CASE: The bronchial brush smears from an 80-year-old female with an endobronchial obstructive tumor showed single and loose clusters of tumor cells with abundant granular, eosinophilic cytoplasm. The differential diagnoses included oncocytic carcinoid tumor, granular cell tumor, other oncocytic tumors of bronchial origin and metastatic oncocytic tumors. Immunocytochemistry and electron microscopy confirmed the diagnosis of oncocytic carcinoid tumor. CONCLUSION: Oncocytic carcinoid tumor of the lung has cytopathologic features similar to those of granular cell tumor and pulmonary oncocytoma. Immunocytochemistry, electron microscope or both are necessary to distinguish these neoplasms.
PMID: 10740615 [PubMed - indexed for MEDLINE]
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Fine needle aspiration cytology of carcinoid tumors.
Collins BT, Cramer HM.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
OBJECTIVE: To define the cytomorphologic features of carcinoid tumor. STUDY DESIGN: The study consisted of 19 carcinoid tumors sampled by fine needle aspiration. These included 6 pulmonary carcinoids. 11 intestinal carcinoids and 2 aspirates from a patient with a mediastinal carcinoid. The cytomorphologic features of carcinoid tumor were documented, and, in selected cases, immunocytochemical findings were noted. Additionally, the cytology literature concerning carcinoid tumor was reviewed and summarized. RESULTS: Morphologically, the carcinoid tumors consisted predominantly of loose groups with a background of single cells. A striking degree of cellular and nuclear monomorphism was seen in all cases. Nuclei were small and round to oval, and all exhibited a characteristic finely granular, evenly distributed chromatin pattern. Cytoplasm was minimal to moderate in amount and finely granular in appearance. Necrosis and prominent nucleoli were not seen. Positive staining was noted in all seven cases in which immunostaining for chromogranin was performed. Neuron-specific enolase was positive in four of five cases. CONCLUSION: The cytomorphologic characteristics of carcinoid tumors are distinctive, and appropriate ancillary studies can assist in confirming the diagnosis.
PMID: 8693889 [PubMed - indexed for MEDLINE]
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Cytopathology of pulmonary carcinoid tumors in sputum and bronchial brushings.
Nguyen GK.
Department of Laboratory Medicine and Pathology, University of Alberta Faculty of Medicine and Hospitals, Edmonton, Canada.
OBJECTIVE: To study the cytologic manifestations of bronchial carcinoid tumor (BCT) in sputum and bronchial brushing (BB). STUDY DESIGN: A diagnosis of BCT was made by sputum examination in 1 case and by BB cytology in 12 cases with central and typical BCTs. The tumor was suspected in three patients whose sputa were too scanty in diagnostic cells. Three patients with central and typical BCTs yielded only a few tumor cells in BB samples and were suspected of having BCT. In three patients with central and atypical BCT, a diagnosis of oat cell carcinoma was made in two cases and typical BCT in the third case by BB. One case of peripheral and typical BCT was correctly identified by BB. In BB samples the typical BCTs showed tumor cells singly and in loose clusters. They displayed oval nuclei, fine chromatin clumping, micronucleoli and ill-defined, variable cytoplasm. The number of tumor cells with plasmacytoid configuration varied from case to case and was abundant in one patient. The peripheral BCT was predominantly composed of spindle cells and in BB samples showed single and loosely clustered cells with ill-defined cytoplasm and cigar-shaped nuclei. Two atypical BCTs yielded pleomorphic cells displaying scant cytoplasm, nuclear molding, fine chromatin and rare micronucleoli, similar to those of oat cell carcinoma, but the smear background was free of necrotic debris. CONCLUSION: BCTs rarely exfoliate their cells in sputum, and bronchial brushing is efficient in detecting BCT cells that show distinctive cytologic features of the tumors.
PMID: 7483991 [PubMed - indexed for MEDLINE]
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Capillaries. A cytologic feature of pulmonary carcinoid tumors.
Mitchell ML, Parker FP.
Department of Pathology, Christiana Hospital, Medical Center of Delaware, Newark 19718.
The cytologic features of pulmonary carcinoid tumors have been well described, but most reports have not mentioned capillaries as a prominent finding. Two cases are described in which abundant capillaries in endobronchial brushing and fine needle aspiration specimens were a helpful feature in making the correct diagnosis.
PMID: 2028691 [PubMed - indexed for MEDLINE]
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Fine needle aspiration cytology of pulmonary carcinoid tumors.
Anderson C, Ludwig ME, O'Donnell M, Garcia N.
Department of Pathology, Hartford Hospital, Connecticut 06115.
Twenty-four cases coded as pulmonary carcinoid tumors initially sampled by fine needle aspiration (FNA) biopsy were reviewed in order to determine the cytologic features most useful in making the FNA diagnosis. The diagnosis of carcinoid tumor had been confirmed in 23 cases; the remaining case, though closely resembling a carcinoid tumor on the FNA specimen, proved to be a sclerosing hemangioma of the lung. Comparison of the original and review interpretations of the FNA specimens revealed that all typical spindle cell carcinoids and all atypical carcinoids were correctly diagnosed and classified. Of the 15 typical round cell carcinoids, the original cytologic diagnosis was lymphoma in 2 cases and benign bronchial lining cells in 2 cases. Thus, it appears that diagnostic errors are most likely in "typical" carcinoids. Review of the FNA findings suggests that the frequently stripped cytoplasm (with resulting non-cohesive bare nuclei), coupled with the almost universal plexiform vascularity (seen in 21 of 23 cases), should allow an accurate cytologic diagnosis in virtually all cases.
PMID: 2375219 [PubMed - indexed for MEDLINE]
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Pulmonary spindle cell carcinoid. Needle aspiration biopsy, histologic and immunohistochemical findings.
Fekete PS, Cohen C, DeRose PB.
Department of Pathology, Emory University, Atlanta, Georgia.
Six pulmonary spindle cell carcinoids were reviewed. The patients were asymptomatic women ranging from 56 to 76 years of age. Four cases were diagnosed or suspected by percutaneous needle aspiration biopsy. The four patients treated by wedge resection or lobectomy showed no recurrence during the followup period; one patient was followed radiologically without resection for over five years, during which time the lesion remained stable. The cytologic preparations showed groups and single oval or elongated cells that had nuclei with finely granular, evenly dispersed chromatin, usually one small nucleolus and easily disrupted, finely granular cytoplasm. The histologic sections showed circumscribed or infiltrative neoplasms growing as sheets or vaguely organoid cell masses with vascular, focally hyalinized stroma. Immunoreactivity for chromogranin, neuron-specific enolase, synaptophysin, S-100 protein and Leu-7 was typically present; bombesin, serotonin, insulin and calcitonin were focally present in some cases. No reactivity for adrenocorticotropic hormone, somatostatin, gastrin, vasoactive intestinal polypeptide, pancreatic polypeptide, low-molecular-weight cytokeratin (MAK-6) or carcinoembryonic antigen was observed.
PMID: 2404375 [PubMed - indexed for MEDLINE]
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Fine needle aspiration cytology of atypical carcinoid of the lung.
Frierson HF Jr, Covell JL, Mills SE.
The cytologic features of eight atypical carcinoid tumors of the lung, as observed in fine needle aspiration (FNA) specimens, are described in detail. They were compared with 21 pulmonary squamous-cell carcinomas, 16 adenocarcinomas, 5 small-cell undifferentiated carcinomas, 3 large-cell undifferentiated carcinomas and 1 typical carcinoid tumor. Atypical carcinoid tumor was easily distinguished from the other pulmonary neoplasms in most instances. Only two poorly differentiated squamous-cell carcinomas (one of which had atypical carcinoid as a component) and one small-cell undifferentiated carcinoma had similar cytologic features. One atypical carcinoid also had cytologic features similar to small-cell undifferentiated carcinoma. Because atypical carcinoid and small-cell undifferentiated carcinoma, at times, may be difficult to separate in FNA specimens, surgical resection of all stage I neoplasms with cytologic features evocative of either neoplasm is recommended.
PMID: 3037832 [PubMed - indexed for MEDLINE]
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The cytodiagnosis of well-differentiated neuroendocrine carcinoma. A distinct clinicopathologic entity.
Jordan AG, Predmore L, Sullivan MM, Memoli VA.
Well-differentiated neuroendocrine carcinoma (WDNE) has been recognized as a distinct variant of pulmonary neuroendocrine carcinoma, with characteristic histopathologic and clinical features that separate it from both carcinoid and small-cell carcinoma (SCC). Histologic review of tumors in long-term survivors (greater than two years) with an initial diagnosis of SCC has shown that the majority of these cases are, in fact, better classified as WDNE; the distinction of WDNE from SCC has, therefore, important prognostic and therapeutic implications. A retrospective review of 200 cytologies originally diagnosed as SCC was undertaken in an attempt to characterize the cytomorphologic features of WDNE. The cytologic criteria that distinguished cases of WDNE included polygonal-to-fusiform cells with a variable amount of lacy cytoplasm, oval nuclei with coarsely dispersed chromatin and frequent chromocenters, and mild nuclear and cytoplasmic anisomorphism. The majority of malignant cells were arranged either in acinarlike clusters or in epithelial sheets with evidence of palisading. Twenty-two cases were reclassified cytologically as WDNE and were accurately distinguished from all other neoplastic and SCC cases on repeated double-blind review. Clinical and histologic data confirmed the diagnosis of WDNE in all cases; it can be concluded that SCC and SDNE are cytologically distinct entities.
PMID: 3037831 [PubMed - indexed for MEDLINE]
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Cytology of pulmonary carcinoid tumors.
Gephardt GN, Belovich DM.
PMID: 6957094 [PubMed - indexed for MEDLINE]
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Cytomorphology of carcinoid tumors.
Lozowski W, Hajdu SI, Melamed MR.
This report is based on a review and study of carcinoid tumors as seen in smears prepared from exfoliative or aspiration smears. During a period of eight years (1970 to 1978), 236 cytologic specimens were examined from 64 patients treated for carcinoid tumors at Memorial Hospital. Thirty-eight cytologic specimens from 18 patients were interpreted as either suspicious or positive for malignant cells. Tumor cells were identified most often in tracheobronchial specimens, effusions and percutaneous aspirates. A striking similarity in cell morphology was found between exfoliated and aspirated tumor cells. Certain specific or suggestive cytologic features were recognized. The histogenesis of carcinoids and the role of intracytoplasmic neurosecretory granules in the differential diagnosis is discussed together with the clinicopathologic implication of positive cytologic findings.
PMID: 230682 [PubMed - indexed for MEDLINE]
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Malignant oncocytoma of a submandibular salivary gland.
Gupta S, Sodhani P.
Publication Types:
PMID: 10834023 [PubMed - indexed for MEDLINE]
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Bronchial oncocytoma diagnosed by brushing cytology.
Kumar PV, Monabati A.
Publication Types:
PMID: 9684608 [PubMed - indexed for MEDLINE]
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Pulmonary oncocytoma. Report of a case with cytologic, histologic and electron microscopic study.
Cwierzyk TA, Glasberg SS, Virshup MA, Cranmer JC.
The cytology of a pulmonary oncocytoma diagnosed by bronchial brushings is described along with the light and electron microscopic findings. Ultrastructurally, the tumor cells showed mitochondrial hyperplasia and an absence of neurosecretory granules. The possible histogenesis of pulmonary oncocytomas is discussed.
PMID: 2992204 [PubMed - indexed for MEDLINE]
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Aspiration biopsy of salivary gland tumors. II. Morphologic studies on smears and histologic sections from oncocytic tumors (45 cases of papillary cystadenoma lymphomatosum and 4 cases of oncocytoma).
Eneroth CM, Zajicek J.
PMID: 5214054 [PubMed - indexed for MEDLINE]
Comment on:
Cytopathology of adrenal cortical oncocytoma.
Wragg T, Nguyen GK.
Publication Types:
PMID: 11241910 [PubMed - indexed for MEDLINE]
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Cytologic features of oncocytic pleomorphic adenoma.
Jimenez-Heffernan JA, Ortega L, Viguer JM.
Publication Types:
PMID: 11169898 [PubMed - indexed for MEDLINE]
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Multicentric oncocytoma of the lung diagnosed by fine-needle aspiration.
Laforga JB, Aranda FI.
Department of Pathology, Hospital Marina Alta, Denia, Alicante, Spain. [email protected]
A 50-yr-old man presented with dyspnea. On chest X-ray, multiple pulmonary nodules were observed. Fine-needle aspiration biopsy (FNAB) showed tridimensional aggregates of atypical round epithelial cells, containing numerous cytoplasmic granules. The tissue fragment confirmed the presence of an epithelial tumor composed of trabecular sheets of clear cells, with numerous cytoplasmic granules which stained with phosphotungstic acid hematoxylin (PTAH). Immunohistochemically, the tumor cells were positive for cytokeratins and antimitochondrial antigen, whereas chromogranin, synaptophysin, S-100 protein, and HMB-45 were negative. Clinical and tomographic studies ruled out any tumor mass elsewhere. The rarity of this lesion in the lung and the potential difficulties for its diagnosis prompted us to report the clinical, cytological, and immunohistochemical findings in this case.
PMID: 10405810 [PubMed - indexed for MEDLINE]
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Oncocytic carcinoma of parotid gland: fine-needle aspiration and histologic findings.
Laforga JB, Aranda FI.
Department of Pathology, Hospital Comarcal de Alcoy, Alicante, Spain.
A parotid gland mass in an elderly man was diagnosed as an oncocytic neoplasm with cellular pleomorphism and cytologic atypia by fine-needle aspiration. The histologic features showed a primary parotid malignant oncocytoma with metastasis in regional lymph nodes.
PMID: 7895576 [PubMed - indexed for MEDLINE]
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Items 1-21 of 21 |
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One page. |
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