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Items 1-5 of 5 |
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Fine needle aspiration cytology of sarcomas metastatic to the lung.
Kim K, Naylor B, Han IH.
A review was made of the morphologic features of cells aspirated from 17 sarcomas (5 malignant fibrous histiocytomas, 3 fibrosarcomas, 3 leiomyosarcomas, 3 endometrial stromal sarcomas, 1 osteosarcoma and 2 poorly differentiated sarcomas) metastatic to the lung, paying particular attention to the morphologic differences between the cells of sarcoma and carcinoma and between the cells of the different types of sarcoma. In general, sarcomas were characterized by loosely cohesive, rather flat, cellular aggregates and isolated cells. Three-dimensional cell balls or clusters were not present in any case. Cellular pleomorphism was a common, though not invariable, feature. Each type of sarcoma showed some morphologic distinctiveness; however, certain morphologic features were common to more than one type of sarcoma. By comparing the cytologic features of metastatic sarcomas in aspirates with the histologic features of the primary neoplasms, it should usually be possible to decide if a pulmonary lesion is a metastatic sarcoma.
PMID: 3024433 [PubMed - indexed for MEDLINE]
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Fine needle aspiration cytology of metastatic dermatofibrosarcoma protuberans. A case report.
Perry MD, Furlong JW, Johnston WW.
Report is made of the fine needle aspiration (FNA) cytologic detection of a rare pulmonary metastasis of dermatofibrosarcoma protuberans, a locally aggressive tumor with a low metastatic potential but a high propensity for recurrences. The cytologic findings paralleled those seen on tissue sections and were characterized by tissue fragments displaying a storiform pattern and slender, spindle-shaped cells. Histiocytic differentiation and mitotic figures were also detected in the cytologic preparations. It is concluded that metastatic dermatofibrosarcoma may be accurately diagnosed by FNA cytology.
PMID: 3465142 [PubMed - indexed for MEDLINE]
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Diagnosis of primary fibrosarcoma of the lung by fine-needle aspiration and core biopsy.
Logrono R, Filipowicz EA, Eyzaguirre EJ, Sawh RN.
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0548, USA.
Primary pulmonary sarcomas are uncommon neoplasms. Primary fibrosarcoma of the lung is extremely rare, and only 53 cases have been documented in the literature to date. To our knowledge, the diagnosis of primary lung fibrosarcoma by fine-needle aspiration cytology has never been reported. We report a case of pulmonary fibrosarcoma diagnosed by fine-needle aspiration cytology and core biopsy. The neoplasm consisted of interweaving fascicles of minimally atypical spindle cells with slender nuclei and scant cytoplasm. Positive immunohistochemistry for vimentin along with nonreactivity of tumor cells for keratin, S100 protein, desmin, alpha-smooth muscle actin, and CD34 supported the the diagnosis. The diagnosis was later confirmed by histologic and ultrastructural findings following lobectomy. A meticulous clinical search for a possible primary neoplasm elsewhere was unsuccessful, and lung was established as the primary site. Fine-needle aspiration cytology and core biopsy are reliable methods for establishing a diagnosis of fibrosarcoma.
Publication Types:
- Review
- Review of Reported Cases
PMID: 10420233 [PubMed - indexed for MEDLINE]
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[Primary fibrosarcoma of the lung]
[Article in Russian]
Denisova OP, Guznov GI, Zalit NIu.
A case of primary pulmonary fibrosarcoma in a women of 50 is described as a rare disease which is difficult to diagnose intravitally due to the absence of pathognomonic clinical and roentgenological data. The danger of prolonged time-course observation of the patient with a rounded shadow in the lung is emphasized. The importance of electron microscopic study to specify the morphological diagnosis is demonstrated.
PMID: 7316826 [PubMed - indexed for MEDLINE]
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Aspiration cytology of lung metastasis of monophasic synovial sarcoma. Report of a case.
Costa I, Lerma E, Esteve E, Chivite A, von Schilling B, Prat J.
Department of Pathology, Autonomous University of Barcelona, Spain.
BACKGROUND: Synovial sarcoma usually arises in the extremities of young adults and metastasizes in about 50% of the cases. Fine needle aspiration can reveal those metastases. CASE: A 65-year-old female presented with a solid mass in the left lung from which a fine needle aspirate was taken. Five years earlier her left foot was amputated because of a diagnosis of synovial sarcoma. Aspiration cytology from the lung revealed numerous groups of spindle cells with scant cytoplasm and ovoid nuclei with fine, homogeneous chromatin. Only vimentin was positive. Based on the clinical, cytologic and immunocytochemical studies, a metastasis from synovial sarcoma was considered to be the most accurate cytologic diagnosis. CONCLUSION: This case demonstrates the utility of aspiration cytology in the diagnosis of a metastatic tumor, especially in those organs in which a core or open biopsy might be too aggressive.
PMID: 9990260 [PubMed - indexed for MEDLINE]
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Items 1-5 of 5 |
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One page. |
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