Bobbie next fell in love with Roy DiLucca, mobster and Luke's partner in the disco, who treated Bobbie like a queen and planned to marry her. He died in her arms after being shot while fleeing from his attempted assassination of Senator Mitch Williams.
She then fell in love with Dr. Noah Drake and even went as far as to pretend to be blind in order to keep him. Noah made it clear he did not want to make a commitment. In 1983 she married financier D.L. Brock. Once they were married he became extremely abusive and he was ultimately murdered. She was initially charged with his murder but her attorney Jake Meyer proved that his daughter Terri killed him.
In 1986, Bobbie married Jake Meyer, who had a one night stand with Lucy Coe. When she became pregnant, Jake and Bobbie worked out a deal with her to raise Lucy's child as their own, but Lucy miscarried the baby. Around this time, a DVX agent who had taken the hospital cafeteria hostage scratched Bobbie with a deadly syringe. An antidote was found, but Bobbie was paralyzed.
Bobbie's recovery was helped along by an optimistic and boisterous paraplegic, Martha McKee. Martha, who was suffering from pneumonia, had to move to Colorado after taking a turn for the worse, and Bobbie agreed to raise her kids, 10-year old Skeeter and teenage Melissa. Melissa rebelled, began hanging out with a bad crowd, injured Ruby when she and a friend robbed Kelly's, and fled to Miami with the friend. They fell prey to a pimp who forced them into prostitution. When the spurned boyfriend of Melissa told Bobbie, she flew down to Miami without telling Jake. Posing as a call girl, she planned to alert the cops to the pimp's illegal activities before she had to sleep with him. The police did arrive, arresting him - and Bobbie too! The recently returned Scotty Baldwin bailed her out, but her arrest made headlines in Port Charles; Melissa and Skeeter were taken away from her, and she and Jake weren't allowed to adopt.
Jake left town to help flood victims in Paraguay, partially due to being sick of her need for children. He tried to explain himself through the mail, but Scotty destroyed the letter and put doubts in Bobbie's mind because he wanted Bobbie for himself. After seeing a photo of Jake with his arm around a woman, she divorced Jake; and 4 months passed before she realized Scott's bad ways and dumped him.
Bobbie then met a sophisticated, rich, handsome man, Gregory Howard, in a bar. Unfortunately, he was (unhappily) married. After weeks of talk and flirting, she finally agreed to go on a weekend with him, but a political party drafted him to run for the state assembly. Bobbie was left brokenhearted yet again as she realized his new political career and an affair wouldn't mix.
In 1991, Bobbie treated a patient who bore an amazing resemblance to Luke Spencer. He was her cousin, Bill Eckert; the Eckerts and the Spencers had been strangers for years due to bad blood.
Bobbie desperately wanted a baby and in fact purchased one from the black market. In 1989 she married her good friend and father of her namesake B.J., Dr. Tony Jones. Unbeknownst to her the baby was Cheryl Stansbury's baby. Bobbie tried to keep the truth a secret, but the truth came out (putting a strain on her marriage), and she had to give the baby back to Cheryl. When Cheryl died, Bobbie became embroiled in a custody suit for the baby(Lucas) with Tiffany Donnelly. The court awarded her custody of Lucas in 1992.
Also in 1992, Bobbie began writing letters to ex-convict and cop killer Joseph Atkins after being impressed by his book, Violence Tamed. He wrote back, asking her to help him get parole. Tony went berserk when Atkins began calling Bobbie at home. Bobbie realized she couldn't support Atkins. When she cut off contact, he told her she'd be sorry. Months later, he broke into the Brownstone, holding her and Tony hostage and trying to rape her before finally being caught by the police.
In 1994, while spying for Luke, she began a flirtation with the evil Damian Smith, in fact Tony caught them in the stairwell of General Hospital embracing the day that B.J. was involved in a school bus accident and was killed. Bobbie consummated her romance with Damian after Tony threw her out, but when she learned he had only seduced her as part of a bet with Lucy, she left him to die in the catacombs. They separated and after counseling eventually found their way back to each other, but Tony was emotionally spent, so things were never quite the same with them.
Bobbie and Tony befriended a young woman that came to Port Charles, Carly Roberts, not knowing that she was really the baby that Bobbie had given up for adoption.
On the day of her wedding anniversary to Tony, Bobbie found Tony and Carly in bed together and that was finally the end of their marriage. She then immediately turned to and married Stefan Cassadine. Eventually she realized that all the things her brother Luke and everyone else had been telling her about how horrible a man Stefan was, were true and agreed to help Luke expose him. She drugged a glass of wine he was drinking and thinking he had finished it, removed a medallion from around his neck that was the key they needed to open up a box he had. Stefan had not drank the wine and therefore caught her and threw her out. She went to Puerto Rico and obtained a divorce.
Shortly thereafter, Bobbie learned that the woman her ex-husband (Tony) was engaged to and expecting a baby with, Carly, was really the daughter she had given up so long ago. Carly has a lot of anger toward Bobbie for leaving her, but the two are trying to rebuild their relationship. The birth of Carly's son and Bobbie's first grandchild, Michael, has helped a lot. When Bobbie found out Luke had known for a few years, and had lied to her that her baby had died, she coldly berated him, promising to never forgive what he had done. However, a Spencer is a Spencer, and she did.
Bobbie was aggressively wooed by Jerry Jacks and fell in love with him. The height of her embarrassment was when their sexual exploits in the GH board room were accidentally filmed and showed at the Nurse's Ball. She was devastated when her wedding to Jerry was thwarted by his arrest by FBI agents. Jerry jumped bail and left town after their tearful good-bye. Just before Jerry's arrest, Bobbie was stunned to find her old flame, supposedly dead, Roy DiLucca alive, well and in town. Her feelings about Roy were jumbled, but after Jerry left town, Roy and Bobbie renewed their love.
Bobbie learned Roy was a federal agent, responsible for busting Jerry, but managed to forgive him before he was taken back to jail. With Bobbie and Luke's help, Roy eventually found the evidence to take down corrupt supervisor Larkin, and Bobbie and Roy were finally free to be together.
Their life went on with relative uneventfulness (Roy had to rescue Luke several times; Tony questioned the effect on Lucas Bobbie's relationship with an ex-con might have; Bobbie, not knowing Roy was trying to pay off Mike Corbin's gambling debts, feared Roy was working for Sonny when she saw Roy having meetings with Sorel; Bobbie had to deal with Carly's various crises) until December 2000, when Bobbie found a letter from a woman named Melissa in Roy's apartment. Roy claimed Larkin must have put the letter in there, but he refused to report a break-in. Lying to Roy, Bobbie went to Chicago to visit Melissa. Melissa was a surgical nurse, with a deceased brother named Leo who had run a club with Roy. Bobbie went to see Melissa again with more questions. Roy eventually found out Bobbie had lied to him, but forgave her.
Shortly after, Melissa moved to Port Charles, joined the nursing staff, and was with Roy at every turn. Bobbie, increasingly edgy and jealous, misplaced files and accused Melissa of the deed. Melissa quit her job, but after a few more confrontations with Bobbie, changed her mind and began fighting back.
Bobbie was hysterical when beloved son Lucas suddenly became near-death from a mysterious illness. Roy tried his best to stay true to Bobbie. Meanwhile, Carly begged him to turn Sonny into the feds, hoping Sonny would agree to witness protection. Roy agreed, but the plan backfired on Carly when Sonny refused to cooperate, then dumped her after he learned of her part in the sting.
When Bobbie heard, she flew into a rage, accusing Roy of destroying Carly's happiness. She broke off her relationship with him, shutting out his every attempt to explain, and finally telling him she had set Melissa up with the files. Despite this, Bobbie refused his several attempts at reconciliation. Finally, she softened, and they parted as friends.
The only bright spot in Bobbie's life at this time was Lucas' rapid recovery (unbeknownst to her, Lucas had been poisoned by Helena's puppet, Lucky, and Tony had agreed to her demands in exchange for the cure).
Was Luke's rock when he too was poisoned by Helena. Got involved with Scotty, when Laura spurned him for Luke. When she learned Scotty blackmailed Carly into signing an affadavit saying she saw Sonny and Alexis having sex to win D.A. race, Bobbie dumped him.