Smarajit Das is currently working as a Senior Research Fellow in the hot areas of bioinformatics,i.e .Currently he is working on under the supervision of Dr. J.Chakraborti and in the Computational Biology Group, Indian Association for the Cultivation of Science(IACS)-Jadavpur,Kolkata since 2002 as an Institute Sponsored Scholar.
Abstract of the work is as follows:
We define a score for each codon of RbCl gene of Ectocarpales family of Brown algae, called the codon-impact-parameter. The codons of high score are the impact codons. Correlations are investigated between this parameter and the secondary structural units of the corresponding peptides. It is known that the correlations of synonymous codons to the efficiency of gene expression, or the structural units of the translated product, are species-specific. RuBisCO, the most abundant enzyme on earth, is one of the prime targets of biotechnology because it is one of the slowest. For the codons of the large subunit of this bifunctional enzyme in the Ectocarpales these scores are presented; the high score impact codons found. We show that the translated amino acid residues from these impact codons prefer to be at the boundary regions between the secondary structural units of this RuBisCO enzyme. Some amongst these impact codons such as Asn AAC and Arg CGT correlate to the coil-helix boundary; some others Tyr TAC and Phe TTC prefer the coil-extended strand boundaries. Overall 70-80 % of these impact codons translate to the boundary region between the secondary structural units of the enzyme. In view of the significance of the boundaries of the enzyme-secondary-structural-entities it is not a surprise then that the matrix formed of the codon-impact-parameters of just the impact codons largely reproduce the phylogenetic relations amongst the thirty-four Ectocarpales. The correlations identify the codons at the boundaries of the secondary structural units and are, therefore, useful in structure prediction routines from m-RNA.

He is also working in the area of analysis of Pallindromes in a genome sequence for their significance in a genome.